{"id":"W4321368021","doi":"10.1016/j.isci.2023.106258","title":"Osmotically evoked PLCδ1-dependent translocation of ΔN-TRPV1 channels in rat supraoptic neurons","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"College of Education, University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Vasopressin; Osmoregulation; Exocytosis; Cell biology; Homeostasis; Chromosomal translocation; Plasma osmolality; Chemistry; TRPV1; Osmoreceptor; Hypertonic saline; Supraoptic nucleus; Internal medicine; Tonicity; Endocrinology; Biophysics; Biology; Biochemistry; Secretion; Transient receptor potential channel; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005472918,0.0001347969,0.0001825345,0.0003242197,0.0001317468,0.00004839937,0.0005463985,0.00006613562,0.00007175023],"category_scores_gemma":[0.0006000231,0.0001143123,0.00005976703,0.001941447,0.0003489987,0.0002943846,0.00008256504,0.0001713421,0.0002159087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002335914,"about_ca_system_score_gemma":0.0001044001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003396058,"about_ca_topic_score_gemma":0.00002024765,"domain_scores_codex":[0.9979266,0.0001295348,0.0003448687,0.0005269216,0.0006073767,0.0004646868],"domain_scores_gemma":[0.9993054,0.0002544129,0.00007718233,0.0002101261,0.00004317368,0.0001097548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001345826,0.00009566161,0.0001075219,0.00002226719,4.573842e-7,0.00002641909,0.001555911,0.01016926,0.9828134,0.002163459,0.0001141367,0.002918006],"study_design_scores_gemma":[0.0003779676,0.0001399327,0.0008194067,0.00005431666,0.000002808172,0.00001356546,0.000224404,0.03826613,0.9588264,0.0008268304,0.0002745721,0.0001736617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940387,0.00002789068,0.0006239748,0.002020805,0.00199212,0.0002965733,0.000007010315,0.0001058099,0.0008871301],"genre_scores_gemma":[0.998309,0.0001398323,0.00003586739,0.0001695031,0.00004927259,0.00001992458,0.000001156968,0.00001338684,0.001262049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02809688,"threshold_uncertainty_score":0.4661521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04386634639296373,"score_gpt":0.28645245795931,"score_spread":0.2425861115663463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}