{"id":"W4321369665","doi":"10.1038/s41590-023-01437-w","title":"Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury","year":2023,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Eye Institute","keywords":"Microglia; Retina; Neuroscience; Biology; Central nervous system; Cell type; Retinal; Cell biology; Immune system; Neuroglia; Inflammation; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003428186,0.0003358443,0.0004473444,0.0006173772,0.0002204695,0.00005419343,0.0006285711,0.0004423501,0.00004767458],"category_scores_gemma":[0.0007251113,0.0003366992,0.0001412396,0.001233759,0.0001374133,0.0001333297,0.0002483829,0.0008652486,0.0004692466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009879747,"about_ca_system_score_gemma":0.0001011001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006985581,"about_ca_topic_score_gemma":0.00000246425,"domain_scores_codex":[0.9964598,0.0008927094,0.0007284769,0.0008000574,0.0004389925,0.0006799473],"domain_scores_gemma":[0.998181,0.0005092021,0.0003864195,0.0006062566,0.0001679888,0.0001491467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008845727,0.0000967921,0.00003549467,0.00007281399,0.000005960932,0.0002521603,0.0001380578,0.0001915645,0.9954938,0.0006774761,0.001940667,0.0002106593],"study_design_scores_gemma":[0.0006621379,0.0007244521,0.001522844,0.00004519214,0.00001615512,0.00007207235,0.00007135385,0.003462771,0.9906998,0.00002223336,0.002429779,0.0002712424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944296,0.00004057697,0.0004119051,0.0008345048,0.002718639,0.00070613,0.0001501349,0.0004568892,0.0002515792],"genre_scores_gemma":[0.9943628,0.00002095496,0.0004597131,0.0006401062,0.00006496959,0.00002655116,0.00003611049,0.00006671562,0.004322052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004794015,"threshold_uncertainty_score":0.9999085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291268029976317,"score_gpt":0.256689436058226,"score_spread":0.2437767557584628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}