{"id":"W4321370231","doi":"10.1001/jamanetworkopen.2023.0147","title":"Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Grand Challenges Canada; University of Toronto; King's College London; Department of Psychiatry, University of Toronto; Fondation Brain Canada; Centre for Addiction and Mental Health Foundation; Wellcome Trust; National Institute for Health and Care Research; Medical Research Council; Sanofi","keywords":"Tolerability; Medicine; Clinical Global Impression; Placebo; Adjunctive treatment; Internal medicine; Major depressive disorder; Depression (economics); Randomized controlled trial; Hamilton Anxiety Rating Scale; Anxiety; Antidepressant; Clinical trial; Psychiatry; Adverse effect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000251101,0.0002912956,0.000398041,0.00008378691,0.0002190249,0.0001282943,0.0005657135,0.00009348732,0.00006392926],"category_scores_gemma":[0.0002971902,0.0001803674,0.0000841681,0.0008303765,0.0001591777,0.0002964243,0.0002482745,0.0001449695,0.00006629365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004772715,"about_ca_system_score_gemma":0.00003973184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001876115,"about_ca_topic_score_gemma":0.0001298258,"domain_scores_codex":[0.9976509,0.0006310867,0.0002319732,0.0006664539,0.0003488807,0.0004707666],"domain_scores_gemma":[0.9970825,0.002059819,0.0002548289,0.0004515884,0.00002897713,0.0001223163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09140887,0.0009459793,0.270933,0.000306282,0.0003809195,0.00119895,0.004422991,0.09339748,0.02148438,0.000881127,0.02112194,0.4935181],"study_design_scores_gemma":[0.02149018,0.01287061,0.5289826,0.002756751,0.00009059256,0.000005199574,0.0002447191,0.008760761,0.4230738,0.0002189035,0.0007749783,0.0007308613],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896381,0.00004317669,0.0000121733,0.00006585063,0.0001237344,0.001739704,0.00004732937,0.0001215241,0.008208394],"genre_scores_gemma":[0.9986513,0.00003625734,0.00002149456,0.0001506865,0.00008599945,0.0003207821,0.00003115232,0.00004596475,0.0006563682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4927872,"threshold_uncertainty_score":0.735517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131086342631651,"score_gpt":0.2676677639473675,"score_spread":0.256356900521051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}