{"id":"W4321372568","doi":"10.1093/neuonc/noad031","title":"Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: Safety, efficacy, biomarker, and pharmacokinetics—CheckMate 908","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; Sidney Kimmel Comprehensive Cancer Center; National Institutes of Health; Hospital for Sick Children; Great Ormond Street Hospital for Children; National Institute for Health and Care Research; Centre de Recherche en Cancérologie de Marseille; Brain Tumour Charity; Murdoch Children's Research Institute; Children’s Hospital of Wisconsin Research Institute; Alder Hey Children's NHS Foundation Trust; Morgan Adams Foundation; Children's Hospital Colorado; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Bristol-Myers Squibb","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Oncology; Clinical endpoint; Adverse effect; Cancer; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007940786,0.0002147036,0.0005138948,0.0001642425,0.0001382979,0.0004506415,0.0003243743,0.0002521266,0.001339883],"category_scores_gemma":[0.0008487287,0.0001160632,0.0004803698,0.0002605481,0.0002104012,0.0003244953,0.0001933059,0.000965755,0.0002222118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009478724,"about_ca_system_score_gemma":0.00098458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072963,"about_ca_topic_score_gemma":0.005081529,"domain_scores_codex":[0.9997959,0.0000784661,0.00001761596,0.00003558034,0.00004483323,0.00002771375],"domain_scores_gemma":[0.9995626,0.00009586157,0.0001812342,0.00002466772,0.00003690366,0.00009869679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1572619,0.004957242,0.140889,0.002179451,0.002080879,0.000492181,0.0003181265,0.005297983,0.05354659,0.0006237067,0.01254698,0.619806],"study_design_scores_gemma":[0.09981777,0.237326,0.554725,0.0007432258,0.003938472,0.003819323,0.0002445214,0.008335034,0.034499,0.0005608989,0.05590175,0.00008899377],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826809,0.01343585,0.0003976905,0.0004244239,0.00004050084,0.0002224753,0.0007117972,0.0000658373,0.002020556],"genre_scores_gemma":[0.993912,0.003234289,0.0009096477,0.0004113186,0.00004385484,0.0001476179,0.0009389581,0.00001116165,0.0003911971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339883,"threshold_uncertainty_score":0.006877363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02134899312938557,"score_gpt":0.2924929071080651,"score_spread":0.2711439139786795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}