{"id":"W4321373232","doi":"10.3390/genes14020518","title":"Genetic Interaction of tRNA-Dependent Mistranslation with Fused in Sarcoma Protein Aggregates","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Transfer RNA; Biology; Protein biosynthesis; Mutant; Protein aggregation; Translation (biology); HEK 293 cells; Mutation; Cell biology; Biochemistry; Cell culture; Molecular biology; Genetics; RNA; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572199,0.00027583,0.0001993946,0.0001220377,0.0001286469,0.0001748817,0.0001799861,0.0002794397,0.0004952361],"category_scores_gemma":[0.0001794097,0.0001001614,0.000207648,0.0001209651,0.0001616862,0.0001085529,0.0002323222,0.0003103284,0.0001625133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003588175,"about_ca_system_score_gemma":0.0001490416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007771553,"about_ca_topic_score_gemma":0.001064171,"domain_scores_codex":[0.9997762,0.00006276674,0.00002607475,0.00003807859,0.00007074736,0.00002612351],"domain_scores_gemma":[0.9998657,0.00004660639,0.00003781369,0.0000192268,0.000009834815,0.00002079657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002900263,0.000009713644,0.00006846892,0.0000076583,0.00000314086,0.00003971795,0.000008479051,0.00006002799,0.9994144,0.00007949452,0.00001351798,0.0002664296],"study_design_scores_gemma":[0.000003918645,0.0001111737,0.0007168421,0.000001160586,0.000004999939,0.0001418043,0.00000637461,0.001407091,0.9966739,0.0000201631,0.0009099547,0.000002572384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958766,0.0003643372,0.002682605,0.00004494352,0.00002277206,0.00002569058,0.00009893361,0.00004232228,0.0008418854],"genre_scores_gemma":[0.9967842,0.0002180699,0.001885498,0.00002014238,0.000004301167,0.00001644701,0.0001556923,0.00001562506,0.0008999351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007771553,"threshold_uncertainty_score":0.002603412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145976387445829,"score_gpt":0.2548820384225706,"score_spread":0.2402843996779877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}