{"id":"W4321373396","doi":"10.3390/ijms24044218","title":"MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Epigenetics; DNA methylation; Rett syndrome; Biology; Chromatin; Methylation; Chromatin remodeling; Genetics; Epigenomics; Histone; DNA; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211335,0.0003988699,0.0004274824,0.0005596904,0.0002326025,0.0004781778,0.0003344271,0.0004758314,0.00174929],"category_scores_gemma":[0.0002590804,0.0001071427,0.0002214259,0.0005753776,0.0002337898,0.0003142791,0.0003583249,0.0004969302,0.0007425337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005007543,"about_ca_system_score_gemma":0.0004368155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405158,"about_ca_topic_score_gemma":0.00130248,"domain_scores_codex":[0.9999173,0.00001099531,0.000008198728,0.00002167167,0.00002657736,0.00001527532],"domain_scores_gemma":[0.9999474,0.00001073371,0.00001392136,0.000001785135,0.00001678487,0.000009333336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004178808,0.00006116889,0.007676199,0.007319233,0.0002868412,0.005063945,0.0003368649,0.001022468,0.2216199,0.01335587,0.04075518,0.7020845],"study_design_scores_gemma":[0.00002396204,0.0001286953,0.02144903,0.0007166028,0.000223512,0.01171917,0.0001478638,0.0005958109,0.05908607,0.003845702,0.902015,0.00004860634],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02021836,0.9564009,0.006317825,0.002103624,0.0007560718,0.0000390814,0.001058211,0.0002565008,0.01284934],"genre_scores_gemma":[0.1156046,0.8593574,0.005543435,0.001095104,0.0007207638,0.00006951253,0.002009496,0.00003959765,0.01556015],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00174929,"threshold_uncertainty_score":0.005851924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06168148986623925,"score_gpt":0.3502872718044169,"score_spread":0.2886057819381777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}