{"id":"W4321374003","doi":"10.1161/circulationaha.122.061451","title":"Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Novartis Institutes for BioMedical Research; National Institutes of Health; Vanderbilt University Medical Center; Boston Scientific Corporation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Broad Institute; Vanderbilt University; Genentech; AstraZeneca; U.S. Department of Veterans Affairs","keywords":"Medicine; Stenosis; Genome-wide association study; Genetics; Internal medicine; Gene; Single-nucleotide polymorphism; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007672365,0.0001965952,0.0001736663,0.0005537555,0.0006414445,0.0003787549,0.0003824472,0.0002307594,0.002404704],"category_scores_gemma":[0.001371536,0.0001310708,0.0003135516,0.0006277963,0.0002565809,0.0001208236,0.0005085808,0.0004223424,0.0001202522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067828,"about_ca_system_score_gemma":0.0004183725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009332941,"about_ca_topic_score_gemma":0.01194827,"domain_scores_codex":[0.999684,0.0001172372,0.0000118927,0.00009127459,0.00004269798,0.00005295839],"domain_scores_gemma":[0.9992874,0.0001475474,0.0002230344,0.0001007772,0.00008304141,0.0001582796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002276576,0.00006246653,0.9925057,0.000006615255,0.000148427,0.0002582276,0.0002969496,0.000105304,0.001644904,0.000170677,0.000457889,0.004115148],"study_design_scores_gemma":[0.0000212056,0.0001007672,0.997682,0.000004353856,0.00006349826,0.0003446987,0.0002204957,0.0006477027,0.0002464785,0.0001652482,0.0005007097,0.000002756225],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993417,0.00002353926,0.0002392689,0.00009692417,0.00000168588,0.000003378205,0.0001342342,0.000008042238,0.0001513241],"genre_scores_gemma":[0.9993371,0.00001535456,0.0002514955,0.00002815406,0.000002709909,0.000005128527,0.0001609473,0.000005456915,0.0001935987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009332941,"threshold_uncertainty_score":0.01855725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04043468184689789,"score_gpt":0.3497708957658285,"score_spread":0.3093362139189306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}