{"id":"W4321374071","doi":"10.1161/circulationaha.121.057844","title":"Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital; University of Calgary; SickKids Foundation; McMaster University; Population Health Research Institute","funders":"CytoSorbents Europe; LEO Pharma; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; CSL Behring; Pfizer Canada; Alexion Pharmaceuticals; Novo Nordisk; Daiichi Sankyo Europe; Sanofi; GlaxoSmithKline; Bayer; Servier; Pfizer","keywords":"Medicine; Rivaroxaban; Apixaban; Edoxaban; Internal medicine; Population; Major bleeding; Hemostasis; Atrial fibrillation; Anesthesia; Surgery; Warfarin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035276,0.00007029358,0.0001762684,0.0001587852,0.00004993102,0.00000982425,0.00001858582,0.0000317031,0.00003203694],"category_scores_gemma":[0.000104243,0.00005693684,0.00005492802,0.0003027048,0.00001184475,0.000082362,0.00001220734,0.00002632376,0.000006050665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002533044,"about_ca_system_score_gemma":0.00002326927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000129029,"about_ca_topic_score_gemma":0.000004786609,"domain_scores_codex":[0.9992508,0.000009169045,0.0002607204,0.0001528412,0.0002305274,0.00009593324],"domain_scores_gemma":[0.9995425,0.00006106158,0.0001505926,0.0001256983,0.00009052909,0.00002965289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001230028,0.000008964927,0.9951521,0.00007510888,0.00007767424,0.00001797893,0.000277506,0.0003128009,0.002429936,0.00006498914,0.0002348283,0.001225155],"study_design_scores_gemma":[0.001862403,0.0001629551,0.9943641,0.00002981594,0.0001467331,0.000008191118,0.0004481735,0.001468721,0.0004255535,0.00005982313,0.0009577783,0.00006578149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967433,0.000007662237,0.001195081,0.0003522962,0.0001687397,0.001097608,0.000003121042,0.00008192654,0.0003502925],"genre_scores_gemma":[0.9985369,8.881154e-7,0.0001851999,0.000009098449,0.0004005246,0.000006990347,0.0001356685,0.00001328661,0.0007114272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002004382,"threshold_uncertainty_score":0.2321817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266245444366116,"score_gpt":0.3600261947670884,"score_spread":0.2334016503304768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}