{"id":"W4321374183","doi":"10.1161/circulationaha.122.063716","title":"Exploring the Relationship Between Efpeglenatide Dose and Cardiovascular Outcomes in Type 2 Diabetes: Insights From the AMPLITUDE-O Trial","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Medical Research Council; National Institutes of Health; Impulse Dynamics; National Medical Research Council; Cytokinetics; Amarin Corporation; Boston Scientific Corporation; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; McMaster University; Amgen; Pfizer; Novo Nordisk; ReCor Medical; Intarcia Therapeutics; Daiichi Sankyo Europe; Kowa Company; Sanofi; Abbott Laboratories","keywords":"Medicine; Mace; Hazard ratio; Internal medicine; Placebo; Myocardial infarction; Renal function; Diabetes mellitus; Cardiology; Type 2 diabetes; Stroke (engine); Angina; Percutaneous coronary intervention; Endocrinology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005564545,0.0005469648,0.001537744,0.0002000358,0.0001620251,0.001082724,0.0003979605,0.0008823835,0.001771388],"category_scores_gemma":[0.00768171,0.0002269804,0.001931327,0.0004528491,0.0004728925,0.0006331709,0.0005978924,0.001548812,0.0001775983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128758,"about_ca_system_score_gemma":0.0004257159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242955,"about_ca_topic_score_gemma":0.0008091392,"domain_scores_codex":[0.9978088,0.001631413,0.0001401038,0.0001432761,0.0001721564,0.0001042966],"domain_scores_gemma":[0.9956335,0.00249353,0.001145032,0.000284763,0.0001714257,0.0002718282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7863151,0.002248656,0.07914352,0.004653303,0.02063468,0.000189795,0.0002628336,0.001584732,0.002767744,0.0009931107,0.002779198,0.09842736],"study_design_scores_gemma":[0.5234753,0.1033356,0.3024237,0.001761786,0.04247926,0.0005595618,0.0004150014,0.00360115,0.002017749,0.005535067,0.01421184,0.0001839897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521978,0.04016805,0.0007888702,0.001857732,0.0002535511,0.0003553875,0.0008718092,0.00002284941,0.003483905],"genre_scores_gemma":[0.9863787,0.009062314,0.001068202,0.001127845,0.0003731174,0.0004209855,0.0009726204,0.00001142823,0.0005849254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005564545,"threshold_uncertainty_score":0.02942848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1699893459780158,"score_gpt":0.296624744486618,"score_spread":0.1266353985086021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}