{"id":"W4321376201","doi":"10.1038/s41401-023-01060-3","title":"Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway","year":2023,"lang":"en","type":"article","venue":"Acta Pharmacologica Sinica","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Hospital for Sick Children; National Key Research and Development Program of China; University of Toronto; National Natural Science Foundation of China","keywords":"Pyroptosis; Programmed cell death; Apoptosis; Cell biology; Mitochondrion; Necroptosis; Cytochrome c; MG132; Proteasome inhibitor; Cytosol; Chemistry; Caspase; Biology; Proteasome; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293988,0.0003943708,0.0003630132,0.0003379161,0.0002262552,0.0003311918,0.0001251998,0.0002555989,0.002056111],"category_scores_gemma":[0.000108662,0.0001387929,0.0002930821,0.0002304518,0.000194862,0.0002027104,0.0002414302,0.0008818493,0.0004387982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003449194,"about_ca_system_score_gemma":0.0002967909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003415006,"about_ca_topic_score_gemma":0.0006750556,"domain_scores_codex":[0.9998651,0.00002386198,0.00001216347,0.00001448976,0.00003836419,0.00004609423],"domain_scores_gemma":[0.9999241,0.00001640964,0.00002253323,0.00001177651,0.000008722768,0.00001656909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001231281,0.0001600648,0.0003279046,0.00008706931,0.00002794386,0.0001523894,0.00001770942,0.0001227423,0.9928762,0.0003855376,0.0001763482,0.004434883],"study_design_scores_gemma":[0.000113112,0.000597914,0.003672977,0.00000516703,0.0000183535,0.0003005484,0.00002159077,0.0005040531,0.9927591,0.0001516773,0.001851305,0.000004188038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867724,0.004144482,0.00284014,0.0002924794,0.00008654618,0.0000867665,0.0004741582,0.0002334099,0.005069591],"genre_scores_gemma":[0.9952824,0.001362112,0.0008296458,0.00006139725,0.00001425697,0.00002970099,0.0003016556,0.00001259581,0.00210631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056111,"threshold_uncertainty_score":0.006878436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716865021702296,"score_gpt":0.262650974715273,"score_spread":0.24548232449825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}