{"id":"W4321378205","doi":"10.3390/pathogens12020353","title":"Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPSc Profile","year":2023,"lang":"en","type":"article","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Canadian Food Inspection Agency","funders":"Canadian Food Inspection Agency","keywords":"Bovine spongiform encephalopathy; Immunohistochemistry; Prion protein; Pathology; Biology; Gene isoform; Lesion; Transmissible spongiform encephalopathy; Pathological; Pathogenesis; Virology; Scrapie; Disease; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003358081,0.0002727984,0.0001753238,0.0007362012,0.000122205,0.0002704508,0.0001064937,0.0002725496,0.0006700458],"category_scores_gemma":[0.0003299941,0.0001572928,0.00008262392,0.0001894616,0.0004202604,0.0002132547,0.0001982127,0.0001416073,0.0001811925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009048509,"about_ca_system_score_gemma":0.00008989433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474978,"about_ca_topic_score_gemma":0.0009617016,"domain_scores_codex":[0.9998356,0.00002827663,0.00002299007,0.00003997581,0.00003773884,0.00003533941],"domain_scores_gemma":[0.9997079,0.000059463,0.00007840437,0.00002043121,0.00007067833,0.00006305823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002848165,0.00003178429,0.01798286,0.0000867144,0.00001908545,0.0003923175,0.0001011572,0.00002863817,0.9795184,0.00005482466,0.00001569555,0.001483847],"study_design_scores_gemma":[0.00003716964,0.001477194,0.7082409,0.0000464047,0.0001291763,0.01006831,0.0008700505,0.001229926,0.2763835,0.0002900265,0.00120359,0.00002378004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977697,0.0004459134,0.001116993,0.000008365247,0.000003576883,0.00001386169,0.00007333429,0.000007494241,0.0005607288],"genre_scores_gemma":[0.9969816,0.0004931748,0.001908249,0.00002395771,0.000008270757,0.0000126634,0.0002030659,0.000003604199,0.0003653984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007362012,"threshold_uncertainty_score":0.002241552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00933820731375316,"score_gpt":0.2565216798163087,"score_spread":0.2471834725025555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}