{"id":"W4321378205","doi":"10.3390/pathogens12020353","title":"Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPSc Profile","year":2023,"lang":"en","type":"article","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Canadian Food Inspection Agency","funders":"Canadian Food Inspection Agency","keywords":"Bovine spongiform encephalopathy; Immunohistochemistry; Prion protein; Pathology; Biology; Gene isoform; Lesion; Transmissible spongiform encephalopathy; Pathological; Pathogenesis; Virology; Scrapie; Disease; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009629675,0.00008485038,0.00009743127,0.00001992117,0.00004682999,0.000008261139,0.00007640867,0.00008884955,0.00002211716],"category_scores_gemma":[0.0001742755,0.00007799536,0.00006064002,0.00007586979,0.00008731979,0.000002106794,0.0001234763,0.00004763772,0.000009361698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007194068,"about_ca_system_score_gemma":0.00002355921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001638742,"about_ca_topic_score_gemma":0.000001052979,"domain_scores_codex":[0.9993638,0.00003514857,0.0001382924,0.0002198358,0.00009446856,0.0001484384],"domain_scores_gemma":[0.9996766,0.00001454573,0.00004506414,0.000157301,0.00003121682,0.00007526856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317033,0.00003908597,0.001943144,0.00003853401,0.00001179708,0.000002172318,0.00002491648,3.246062e-7,0.9807396,0.00007993022,0.004547904,0.01244087],"study_design_scores_gemma":[0.001078667,0.0004423257,0.08586977,0.00007048417,0.00008333537,0.00001984937,0.0001472912,0.001058289,0.8607172,0.000436382,0.04960924,0.0004671767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968364,0.002015295,0.0004032522,0.0001622408,0.00003558205,0.0001498892,0.0002000177,0.00001806595,0.0001792573],"genre_scores_gemma":[0.998545,0.000285012,0.0002481712,0.00002332288,0.00005936569,0.00004128246,0.0005364009,0.00001254013,0.0002489369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1200224,"threshold_uncertainty_score":0.3180559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00933820731375316,"score_gpt":0.2565216798163087,"score_spread":0.2471834725025555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}