{"id":"W4321380513","doi":"10.1016/bs.ctdb.2023.01.005","title":"Wnt signaling in stem cells during development and cell lineage specification","year":2023,"lang":"en","type":"review","venue":"Current topics in developmental biology/Current Topics in Developmental Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Wnt signaling pathway; Biology; Cell biology; Fibroblast growth factor; Cell fate determination; Stem cell; Bone morphogenetic protein; Hedgehog; Cellular differentiation; Signal transduction; Induced pluripotent stem cell; Embryonic stem cell; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000494368,0.0008455971,0.000934674,0.001230308,0.0001858609,0.001046122,0.0007065237,0.0009843295,0.00299772],"category_scores_gemma":[0.0003635201,0.0003236999,0.000270365,0.001734817,0.0004518804,0.00104085,0.0006630667,0.001291512,0.002355956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008231418,"about_ca_system_score_gemma":0.001297213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355685,"about_ca_topic_score_gemma":0.00257483,"domain_scores_codex":[0.999876,0.00001309357,0.00001682643,0.00002067615,0.00005516096,0.00001816854],"domain_scores_gemma":[0.9998969,0.00003152436,0.00002068029,0.00000438983,0.00002952252,0.00001696044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001603353,0.00004479409,0.000155439,0.01009602,0.0000597677,0.0002397791,0.00004190403,0.00054112,0.01026671,0.007556507,0.0296767,0.941161],"study_design_scores_gemma":[0.00001980998,0.00004123177,0.0006781592,0.001460374,0.00007029819,0.0004489845,0.00003058702,0.0000821092,0.001766034,0.001604515,0.9937869,0.0000110581],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001658464,0.9974192,0.0002855848,0.0002516269,0.0002963567,0.00000429685,0.00002806883,0.000008735255,0.001540227],"genre_scores_gemma":[0.0006006748,0.9976908,0.0001873779,0.0001114051,0.000182901,0.000005509337,0.00004205258,0.000001940777,0.001177344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00299772,"threshold_uncertainty_score":0.01002842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068924775860102,"score_gpt":0.3312760411185222,"score_spread":0.224383563532512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}