{"id":"W4321434652","doi":"10.1101/2023.02.20.529311","title":"Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; McMaster University; Robarts Clinical Trials; McMaster University Medical Centre; Western University","funders":"","keywords":"Biology; TLR3; Virology; CD8; Peripheral blood mononuclear cell; Viral replication; Virus; Immunology; Toll-like receptor; Innate immune system; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206037,0.0004586409,0.0002688045,0.0002044279,0.00009601191,0.0002088411,0.0001517416,0.0003002661,0.001414354],"category_scores_gemma":[0.00007641416,0.00009533716,0.0001641592,0.00006076349,0.0001920895,0.0002392291,0.0001480588,0.0007719451,0.0003484491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197935,"about_ca_system_score_gemma":0.0001068917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001563329,"about_ca_topic_score_gemma":0.0002628413,"domain_scores_codex":[0.9998759,0.00001937514,0.000009503751,0.00003188142,0.00001897878,0.00004434273],"domain_scores_gemma":[0.9999094,0.000009762484,0.00002695434,0.000008555185,0.000008573708,0.00003673507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000300239,0.00007318684,0.00009999907,0.00002562464,0.000002627837,0.00001530783,0.000007124145,0.00004353622,0.9976134,0.0000421951,0.00003571982,0.001740951],"study_design_scores_gemma":[0.00003574125,0.002988623,0.001845302,0.000005587162,0.0000206434,0.000140798,0.0000210348,0.0004996607,0.9928905,0.00003945052,0.001508687,0.000004146241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946653,0.001387625,0.002342927,0.0001033919,0.00005895433,0.00003521163,0.0002400635,0.0001453704,0.001021187],"genre_scores_gemma":[0.9949508,0.0005604828,0.001620568,0.00006255571,0.00002359954,0.00003297731,0.0001854209,0.0000181883,0.002545458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414354,"threshold_uncertainty_score":0.004731476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113072220331353,"score_gpt":0.2022765628984063,"score_spread":0.1911458406950928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}