{"id":"W4321443380","doi":"10.15252/embr.202256524","title":"Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut National Du Cancer; China Scholarship Council; Inserm Transfert; Fondation de France; Science and Technology Commission of Shanghai Municipality; Institut National de la Santé et de la Recherche Médicale; Sanofi; CNIB; Ligue Contre le Cancer","keywords":"Cancer research; Population; Biology; Stromal cell; CD44; Pancreatic cancer; Immunotherapy; Myeloid; Stem cell; KLF4; Cell; Immunology; Cell biology; Cancer; SOX2; Immune system; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576113,0.0001561959,0.0002692211,0.0002108262,0.0001201151,0.0004096325,0.0001160358,0.0003081979,0.002037202],"category_scores_gemma":[0.0001499345,0.0001136086,0.0002005315,0.0001695266,0.000194138,0.0002424265,0.000221612,0.0008832524,0.0004209751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001432734,"about_ca_system_score_gemma":0.0001348919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001597319,"about_ca_topic_score_gemma":0.0002243008,"domain_scores_codex":[0.9998534,0.00003188274,0.0000141922,0.00002096278,0.00003420724,0.00004535952],"domain_scores_gemma":[0.9998829,0.00002994392,0.00002347151,0.00002320428,0.000009762431,0.00003058732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006060541,0.0001640857,0.001037249,0.00006103385,0.00001344854,0.0001806851,0.00004433364,0.000142308,0.9909552,0.0002680469,0.0002907666,0.006236841],"study_design_scores_gemma":[0.0001624766,0.001933747,0.0132716,0.00000614256,0.00004166954,0.0007932407,0.0001136605,0.001417083,0.9756508,0.0001769854,0.006427763,0.000004757824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963456,0.001079646,0.0008073411,0.0001513068,0.00004677184,0.00002535405,0.0001368167,0.0001011227,0.001306045],"genre_scores_gemma":[0.9979913,0.0002769117,0.0003033728,0.00004068892,0.00001337895,0.00002057257,0.0001522594,0.000009933626,0.001191605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002037202,"threshold_uncertainty_score":0.006815076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05856250435267705,"score_gpt":0.3711001913182339,"score_spread":0.3125376869655568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}