{"id":"W4321443822","doi":"10.1101/2023.02.19.529125","title":"The distinctive mechanical and structural signatures of residual force enhancement in myofibers","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Deutsche Forschungsgemeinschaft; U.S. Department of Energy; Office of Science; National Institutes of Health; National Science Foundation","keywords":"Titin; Myofilament; CrossBridge; Isometric exercise; Protein filament; Biophysics; Chemistry; Contraction (grammar); Myofibril; Myosin; Crystallography; Anatomy; Materials science; Sarcomere; Biology; Myocyte; Cell biology; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632515,0.0001182636,0.000132902,0.0004018714,0.0001743171,0.0002177057,0.0001610667,0.0002579457,0.002272449],"category_scores_gemma":[0.0001725283,0.0001374212,0.0001118945,0.0001420431,0.0002940631,0.000179946,0.0002263139,0.000256589,0.0003153446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009404657,"about_ca_system_score_gemma":0.00005716115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290057,"about_ca_topic_score_gemma":0.000281459,"domain_scores_codex":[0.9999394,0.000005354645,0.000005179976,0.00001603393,0.00001989761,0.00001410581],"domain_scores_gemma":[0.9997807,0.00004468413,0.00006250646,0.00003027548,0.00003745603,0.00004441465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001679117,0.00001397405,0.002891028,0.00002692973,0.000005716754,0.0002285702,0.00003990023,0.00002779329,0.9947268,0.0001029654,0.0001311544,0.001637202],"study_design_scores_gemma":[0.00003861589,0.0004060564,0.4390349,0.00001630724,0.00002901834,0.004460412,0.0002034141,0.001393109,0.5503385,0.0005276896,0.003531031,0.00002093869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962831,0.0006210584,0.001522042,0.0001372894,0.00002077021,0.00000594287,0.0002337598,0.00004991394,0.001126071],"genre_scores_gemma":[0.9956172,0.0001820844,0.001402166,0.00006922214,0.00002237417,0.000007943669,0.0003766284,0.00002297634,0.00229949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272449,"threshold_uncertainty_score":0.007602155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155959400355961,"score_gpt":0.2512149289950403,"score_spread":0.2356189889594442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}