{"id":"W4321446455","doi":"10.21203/rs.3.rs-2391364/v1","title":"Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of California, San Diego; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"dNaM; Neuropathology; Biomarker; DNA methylation; Pathological; Medicine; Alzheimer's disease; Disease; Cerebrospinal fluid; Neurology; Pathology; Oncology; Internal medicine; Biology; Psychiatry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002288947,0.0002784684,0.0002668271,0.0004038338,0.0001749721,0.0001423687,0.0002302916,0.0004929811,0.00001503226],"category_scores_gemma":[0.002022467,0.0002959074,0.00011734,0.0003980296,0.0001887536,0.000006867427,0.001132489,0.0005632024,0.00001857588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006784065,"about_ca_system_score_gemma":0.0004076751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004710872,"about_ca_topic_score_gemma":0.001064792,"domain_scores_codex":[0.9965712,0.0009786823,0.0003689926,0.0008695983,0.0006248257,0.0005867463],"domain_scores_gemma":[0.9983307,0.0002446098,0.0001367961,0.0004263341,0.0005743286,0.0002872409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002304345,0.001181878,0.6421829,0.001477783,0.001489368,0.0003808086,0.0007558176,0.0007172182,0.2776414,0.0001428507,0.001724963,0.07000065],"study_design_scores_gemma":[0.0007269297,0.0002176716,0.9698888,0.0003294996,0.00006426789,2.658531e-7,0.00008776505,0.001518414,0.02339689,0.002759997,0.0006094042,0.0004000888],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889005,0.008181335,0.0001741612,0.0003426993,0.0001559496,0.001024396,0.0006716265,0.00003320222,0.0005161459],"genre_scores_gemma":[0.9920616,0.002100972,0.00004933068,0.000009233177,0.0002019031,0.0002187831,0.005094057,0.00006860173,0.0001955796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3277059,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09464631370765748,"score_gpt":0.3917351743004866,"score_spread":0.2970888605928291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}