{"id":"W4321446455","doi":"10.21203/rs.3.rs-2391364/v1","title":"Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of California, San Diego; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"dNaM; Neuropathology; Biomarker; DNA methylation; Pathological; Medicine; Alzheimer's disease; Disease; Cerebrospinal fluid; Neurology; Pathology; Oncology; Internal medicine; Biology; Psychiatry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649798,0.000287543,0.0004422179,0.001035801,0.0002642751,0.0004301592,0.0002118215,0.0003810047,0.002043019],"category_scores_gemma":[0.001656198,0.0001260396,0.0002206735,0.0007455177,0.000243521,0.0001974708,0.0003098143,0.0001681688,0.0002778057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786187,"about_ca_system_score_gemma":0.0002112777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004438786,"about_ca_topic_score_gemma":0.005236104,"domain_scores_codex":[0.9998079,0.00002428909,0.0000243157,0.0000894956,0.00002738316,0.00002663245],"domain_scores_gemma":[0.9993947,0.0001627688,0.0002196058,0.00005093408,0.00007166866,0.0001002855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002194311,0.00006575162,0.9615669,0.0001371938,0.0002287292,0.000592839,0.00055771,0.00009193622,0.02450939,0.00009690234,0.0005436781,0.009414656],"study_design_scores_gemma":[0.00001556875,0.0001022282,0.9979681,0.000006804781,0.00004580509,0.0005040427,0.000115177,0.00009866075,0.0006951873,0.00009828079,0.000345173,0.000005030995],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998163,0.0005085843,0.0001133393,0.00002797963,0.000008081021,0.000005402087,0.0008425213,0.000009598775,0.0003215666],"genre_scores_gemma":[0.9987471,0.0001331554,0.0001206733,0.00003387239,0.00001707568,0.000007110583,0.0006744217,0.000005352265,0.0002611707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004438786,"threshold_uncertainty_score":0.008825898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09464631370765748,"score_gpt":0.3917351743004866,"score_spread":0.2970888605928291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}