{"id":"W4321457978","doi":"10.1002/art.42482","title":"Elevated Levels of Interferon‐α Act Directly on B Cells to Breach Multiple Tolerance Mechanisms Promoting Autoantibody Production","year":2023,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Society; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Pfizer","keywords":"Autoantibody; B cell; Biology; Immunology; Interferon; Flow cytometry; T cell; Cell; Peripheral tolerance; Signal transduction; Cell biology; Receptor; Cytokine; Immune system; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000313606,0.0007164013,0.0004020164,0.000283927,0.0001454705,0.0004898214,0.0001973769,0.0004694222,0.001627487],"category_scores_gemma":[0.0001495558,0.0001526258,0.0003394786,0.0001696007,0.0003042482,0.0002859863,0.0003355172,0.0009386118,0.000640126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823674,"about_ca_system_score_gemma":0.0001572187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001481061,"about_ca_topic_score_gemma":0.0001567166,"domain_scores_codex":[0.9996165,0.00007826648,0.00004914213,0.000068655,0.0001159842,0.00007151706],"domain_scores_gemma":[0.9997931,0.00002602803,0.00008367336,0.00003240322,0.00002562658,0.00003923195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009706457,0.00001429511,0.0003936814,0.00003678254,0.000005642889,0.0000340732,0.000004496686,0.00003067057,0.9984784,0.0000273396,0.000008621562,0.0008690086],"study_design_scores_gemma":[0.00004352504,0.0006082096,0.009306921,0.00003319159,0.00003982105,0.0004271691,0.0000340551,0.0005069404,0.9869757,0.0001107459,0.001909422,0.000004399169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804248,0.006447494,0.01035156,0.0002003539,0.00009467802,0.00005568594,0.0003198978,0.0002162371,0.001889334],"genre_scores_gemma":[0.9906178,0.002147515,0.005797541,0.00009898281,0.00003565404,0.00004637555,0.0002183987,0.00001628853,0.001021543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001627487,"threshold_uncertainty_score":0.005444467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02590987976716602,"score_gpt":0.2974849451336804,"score_spread":0.2715750653665144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}