{"id":"W4321457978","doi":"10.1002/art.42482","title":"Elevated Levels of Interferon‐α Act Directly on B Cells to Breach Multiple Tolerance Mechanisms Promoting Autoantibody Production","year":2023,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Society; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Pfizer","keywords":"Autoantibody; B cell; Biology; Immunology; Interferon; Flow cytometry; T cell; Cell; Peripheral tolerance; Signal transduction; Cell biology; Receptor; Cytokine; Immune system; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009608776,0.0002745664,0.0009345107,0.0005777908,0.0001170156,0.00001787797,0.0002334661,0.0001946977,0.0001307065],"category_scores_gemma":[0.001294078,0.0002621051,0.0001176076,0.0009926943,0.0001063216,0.00009566861,0.0001480697,0.0003276245,0.000915473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105411,"about_ca_system_score_gemma":0.0001584587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001717007,"about_ca_topic_score_gemma":0.0001286534,"domain_scores_codex":[0.9968636,0.000264066,0.0008265942,0.0007500222,0.0005370017,0.0007587234],"domain_scores_gemma":[0.9982277,0.0003572294,0.0002082335,0.0006781786,0.0003187595,0.0002098845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004425696,0.0002438603,0.03451021,0.0008315411,0.000106476,0.0001130931,0.003996694,0.00003618243,0.9422742,0.0005562889,0.001985218,0.01490368],"study_design_scores_gemma":[0.003068272,0.001574705,0.004829953,0.006478246,0.00001587496,0.01018087,0.0008400696,0.00280351,0.969225,0.0002518551,0.0003982029,0.0003334128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947761,0.0001544275,0.0003294506,0.001265786,0.001090305,0.001607608,0.00002983557,0.0004598096,0.0002866331],"genre_scores_gemma":[0.9980844,0.0001973551,0.0006461086,0.00005941857,0.00003782256,0.0001615851,0.00003276308,0.00007882925,0.0007017481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02968026,"threshold_uncertainty_score":0.9999831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02590987976716602,"score_gpt":0.2974849451336804,"score_spread":0.2715750653665144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}