{"id":"W4321460409","doi":"10.1016/j.jinorgbio.2023.112164","title":"Multifunctional metallochaperone modifications for targeting subsite cavities in mutant p53-Y220C","year":2023,"lang":"en","type":"article","venue":"Journal of Inorganic Biochemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; Simon Fraser University","funders":"National Cancer Institute; Simon Fraser University; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale; Centre National de la Recherche Scientifique; Natural Sciences and Engineering Research Council of Canada; Association pour la Recherche sur le Cancer","keywords":"Chemistry; Mutant; Small molecule; Cytotoxicity; Binding site; Bifunctional; Point mutation; Ligand (biochemistry); Stereochemistry; Biochemistry; Biophysics; Receptor; Gene; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906244,0.0001306323,0.0001714127,0.00009139799,0.00009102749,0.00002536577,0.0002232546,0.0001515104,0.00003861441],"category_scores_gemma":[0.00024893,0.0001236536,0.0001431412,0.0002502131,0.00006163635,0.000009499548,0.00004288592,0.0001458106,0.000006103758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006201012,"about_ca_system_score_gemma":0.0002411971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006521286,"about_ca_topic_score_gemma":0.000005572652,"domain_scores_codex":[0.9989191,0.00001903789,0.0004793521,0.0002059416,0.0001625889,0.0002139476],"domain_scores_gemma":[0.9991392,0.00002960871,0.0002657104,0.0002042273,0.000285782,0.000075426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000624677,0.00006150902,0.0004595254,0.00003335141,0.00006268358,0.000002517531,0.00005570112,0.0004400182,0.9943584,0.00003665401,0.004114443,0.0003127796],"study_design_scores_gemma":[0.0008689936,0.00008103627,0.001865052,0.00002892947,0.00003348868,0.00005221528,0.000879646,0.0004969515,0.986665,0.000106416,0.008739555,0.0001827772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944916,0.001384257,0.002943139,0.0006939216,0.0002083962,0.0001023289,0.0000635329,0.0000100548,0.0001028181],"genre_scores_gemma":[0.9963747,0.0004659076,0.001305687,0.00007832921,0.0004903456,0.00002772305,0.0001592545,0.00002424254,0.001073873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00769341,"threshold_uncertainty_score":0.5042449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674078308181069,"score_gpt":0.2614492490921729,"score_spread":0.2447084660103622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}