{"id":"W4321460736","doi":"10.1016/j.bbagrm.2023.194922","title":"Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research","funders":"Mitacs","keywords":"Histone H4; Nucleosome; Methylation; Methyltransferase; Arginine; Histone methyltransferase; Histone; Histone methylation; Biochemistry; Biology; Chemistry; DNA methylation; Amino acid; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007164279,0.0005569864,0.0005112719,0.000482038,0.0002020424,0.00007119811,0.0004172548,0.0006104446,0.00002243387],"category_scores_gemma":[0.00005955016,0.0006219647,0.000285089,0.001066051,0.0001222675,0.00005348008,0.000247374,0.0002474208,0.00007179863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002950047,"about_ca_system_score_gemma":0.0001950103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005055562,"about_ca_topic_score_gemma":0.00001514756,"domain_scores_codex":[0.9964864,0.0003245418,0.0007595591,0.001215535,0.0005067207,0.0007072275],"domain_scores_gemma":[0.9981794,0.00003978724,0.0004771268,0.0009800021,0.0001245374,0.0001991972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003092435,0.0001550263,5.908302e-7,0.00003132009,0.00009793948,0.000002165409,0.0001390975,0.0003722398,0.9923818,0.0002514055,0.002191574,0.004067652],"study_design_scores_gemma":[0.00113308,0.0002811355,0.002068075,0.00003650115,0.00006229524,0.000006439386,0.00006433888,0.002634628,0.9896446,0.002459634,0.0009051052,0.0007041637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994464,0.0005218213,0.001942437,0.001017721,0.0008049991,0.0008268042,0.0001297591,0.0001965484,0.0000959074],"genre_scores_gemma":[0.9924634,0.0005982623,0.001693071,0.0001367247,0.000288207,0.0001641174,0.003292225,0.0001638955,0.001200141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003363488,"threshold_uncertainty_score":0.9996232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021656185263646,"score_gpt":0.2546527322027483,"score_spread":0.2444361703501119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}