{"id":"W4321460736","doi":"10.1016/j.bbagrm.2023.194922","title":"Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Structural Genomics Consortium; University of Toronto; Ontario Institute for Cancer Research","funders":"Mitacs","keywords":"Histone H4; Nucleosome; Methylation; Methyltransferase; Arginine; Histone methyltransferase; Histone; Histone methylation; Biochemistry; Biology; Chemistry; DNA methylation; Amino acid; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005381387,0.0004513913,0.0003609593,0.0001811274,0.0002425367,0.0004264367,0.0005915713,0.000273294,0.002029864],"category_scores_gemma":[0.0004507872,0.0003915572,0.0003351468,0.0002703368,0.0002522899,0.0002841731,0.0006137675,0.0009940861,0.00148586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005510626,"about_ca_system_score_gemma":0.0003060589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001908877,"about_ca_topic_score_gemma":0.003017357,"domain_scores_codex":[0.9996543,0.00007611824,0.00003284584,0.00009767988,0.0000720293,0.00006709971],"domain_scores_gemma":[0.9997556,0.00009664267,0.00003869313,0.0000515639,0.00002207232,0.000035469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005999492,0.00001501263,0.00007216259,0.00003070791,0.000004166471,0.00001402877,0.00002541537,0.00006867741,0.9986981,0.0001269791,0.00004775144,0.0008368912],"study_design_scores_gemma":[0.000003787803,0.00002048958,0.0001457199,0.000001723213,0.000003901416,0.00002033639,0.000005297755,0.0003080681,0.9980928,0.00001792814,0.001377656,0.000002233528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.941812,0.002864722,0.04634583,0.0003522915,0.0001554759,0.0001136811,0.001407758,0.0008254955,0.006122671],"genre_scores_gemma":[0.9754272,0.0009019861,0.01244441,0.00005129248,0.00002095249,0.00004464629,0.002293397,0.00022689,0.008589376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029864,"threshold_uncertainty_score":0.006790578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021656185263646,"score_gpt":0.2546527322027483,"score_spread":0.2444361703501119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}