{"id":"W4321479838","doi":"10.1101/2023.02.22.529502","title":"Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Institute of Genetics; Wellcome Trust","keywords":"Chromatin; Biology; Chromosome; Chromosome conformation capture; Genome; Chromatin immunoprecipitation; Polycomb-group proteins; Genetics; Cell biology; DNA; Gene; Enhancer; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367575,0.000264872,0.0002058806,0.0001893179,0.0001566446,0.0003376694,0.0003056542,0.0002778312,0.001623013],"category_scores_gemma":[0.00009240764,0.0001850774,0.0002144115,0.0001070382,0.0004386143,0.0001694311,0.0003564604,0.000700852,0.0004941853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004681578,"about_ca_system_score_gemma":0.0002413637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127244,"about_ca_topic_score_gemma":0.001698591,"domain_scores_codex":[0.9998388,0.0000233004,0.00001801525,0.00004523742,0.00004286965,0.00003174916],"domain_scores_gemma":[0.9997765,0.00004351551,0.00008245988,0.00003849221,0.00001070152,0.00004825583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002135772,0.000007424203,0.00005611513,0.00001441054,0.000002244545,0.00001599859,0.000006108241,0.00004594087,0.9995433,0.00006763072,0.0000142826,0.0002051694],"study_design_scores_gemma":[0.000006493633,0.00003920867,0.00080769,0.000001766283,0.000003011364,0.0000398897,0.000009044469,0.0003598585,0.9976419,0.00001937559,0.001070349,0.000001462791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890006,0.001190878,0.007189346,0.0002465161,0.00004420865,0.00003541762,0.0004352729,0.000186212,0.001671551],"genre_scores_gemma":[0.9907164,0.0003551295,0.002930636,0.0000954453,0.000009202739,0.0000370648,0.0005212302,0.0000607188,0.005274071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623013,"threshold_uncertainty_score":0.005429506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357423783583075,"score_gpt":0.2387739048197711,"score_spread":0.2251996669839403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}