{"id":"W4321482216","doi":"10.1101/2023.02.21.525740","title":"Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Argonne National Laboratory; U.S. Department of Energy; McGill University; Office of Science; Austrian Science Fund; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"HDAC6; Chemistry; Ubiquitin; Zinc finger; Cell biology; Small molecule; Ubiquitin ligase; Drug discovery; Histone deacetylase; Computational biology; Biochemistry; Biophysics; Cancer research; Histone; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725594,0.000323467,0.0002182269,0.0001675557,0.0001409305,0.0001935851,0.0003026564,0.000382348,0.001184067],"category_scores_gemma":[0.000185693,0.0001077053,0.0002775037,0.000135473,0.0002282985,0.0001199364,0.0001496235,0.0003570612,0.0004573831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262544,"about_ca_system_score_gemma":0.000262511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077414,"about_ca_topic_score_gemma":0.001004164,"domain_scores_codex":[0.9998951,0.00001760142,0.000005168511,0.00002292941,0.00003534603,0.00002386256],"domain_scores_gemma":[0.9999236,0.00001486701,0.00001690051,0.000008065991,0.00001146197,0.00002512358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003075153,0.00001327071,0.00006377423,0.0000148643,0.000003059178,0.00001854492,0.000005305786,0.0001503788,0.9988093,0.00008074837,0.00003157409,0.0007784956],"study_design_scores_gemma":[0.00001113711,0.0001798748,0.0003718642,0.000001512577,0.000005142069,0.00005589,0.000005042531,0.000472292,0.9973464,0.00001733372,0.001531124,0.000002368831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725111,0.001816955,0.0210964,0.0001892368,0.00003408369,0.0001697343,0.00109054,0.0001011177,0.00299089],"genre_scores_gemma":[0.9760953,0.0007963622,0.01732476,0.0001122312,0.00001205952,0.00009085807,0.001452235,0.00002617296,0.004090058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184067,"threshold_uncertainty_score":0.003961146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206317613542968,"score_gpt":0.2345663955378025,"score_spread":0.2225032194023728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}