{"id":"W4321482409","doi":"10.18632/aging.204538","title":"DNAmFitAge: biological age indicator incorporating physical fitness","year":2023,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Institute on Aging; Biotechnology and Biological Sciences Research Council; National Heart, Lung, and Blood Institute; Medical Research Council; Wellcome Trust","keywords":"dNaM; Physical fitness; Epigenetics; VO2 max; Gerontology; Demography; DNA methylation; Medicine; Physical therapy; Biology; Internal medicine; Heart rate; Genetics; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091412,0.0000967903,0.0000962975,0.00004485208,0.0000988336,0.00002617537,0.0001208988,0.00008015728,0.000005140293],"category_scores_gemma":[0.00008650169,0.00008593842,0.00005650976,0.0001313741,0.00005739077,0.000002355994,0.0001482192,0.0000774797,0.00006350884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005855788,"about_ca_system_score_gemma":0.00001936802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005742162,"about_ca_topic_score_gemma":0.00000346281,"domain_scores_codex":[0.9992854,0.00004959848,0.0001160689,0.0002639746,0.00009142817,0.000193551],"domain_scores_gemma":[0.9996594,0.00002365351,0.00005816335,0.0001836733,0.00001856587,0.0000564992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004232172,0.00002057809,0.04144137,0.000007498868,0.00001311993,0.00001768477,0.0001114263,0.0001415457,0.9488111,0.000213718,0.0001378266,0.009079867],"study_design_scores_gemma":[0.0005190904,0.0002329563,0.1591994,0.00002019687,0.00001446036,0.000002644804,0.000194694,0.001470522,0.821154,0.004427005,0.01230395,0.00046106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977238,0.0001705965,0.0009314796,0.0001168322,0.0001034972,0.00007315724,0.000005431357,0.00005143392,0.0008237392],"genre_scores_gemma":[0.99862,0.00005378302,0.0003676186,0.00005975799,0.0004214302,0.00001501877,0.0002418677,0.00001530088,0.000205179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1276572,"threshold_uncertainty_score":0.3504467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671108169255683,"score_gpt":0.2986901851828461,"score_spread":0.2719791034902893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}