{"id":"W4321482409","doi":"10.18632/aging.204538","title":"DNAmFitAge: biological age indicator incorporating physical fitness","year":2023,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Institute on Aging; Biotechnology and Biological Sciences Research Council; National Heart, Lung, and Blood Institute; Medical Research Council; Wellcome Trust","keywords":"dNaM; Physical fitness; Epigenetics; VO2 max; Gerontology; Demography; DNA methylation; Medicine; Physical therapy; Biology; Internal medicine; Heart rate; Genetics; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063615,0.000892173,0.0006392542,0.002090672,0.0002516266,0.001277283,0.0006651017,0.0008851093,0.02919138],"category_scores_gemma":[0.003535992,0.0003414521,0.0004452182,0.001077047,0.0002021917,0.0006774325,0.0008601574,0.0006731754,0.01165678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473778,"about_ca_system_score_gemma":0.0003197031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00318536,"about_ca_topic_score_gemma":0.006162429,"domain_scores_codex":[0.9996696,0.00006987881,0.00002849938,0.0001118716,0.0000942253,0.0000259061],"domain_scores_gemma":[0.9993514,0.0001715008,0.000183537,0.00006334586,0.0001394313,0.00009070433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002432994,0.0003989425,0.4170381,0.0007880444,0.0005778366,0.0002256232,0.0002500154,0.00172632,0.008900047,0.001625632,0.1246049,0.4414315],"study_design_scores_gemma":[0.0002267856,0.001385298,0.798566,0.0003641442,0.000671456,0.001773172,0.0002165335,0.01201185,0.01250631,0.003999687,0.1680857,0.0001931394],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4786671,0.02888657,0.07216629,0.00438653,0.003592674,0.001171649,0.2970397,0.02472924,0.0893603],"genre_scores_gemma":[0.6914943,0.006714536,0.09124162,0.001137317,0.0009054104,0.002009496,0.08468004,0.001816193,0.120001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02919138,"threshold_uncertainty_score":0.09765488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671108169255683,"score_gpt":0.2986901851828461,"score_spread":0.2719791034902893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}