{"id":"W4321482739","doi":"10.1038/s41375-023-01856-6","title":"Patients with Down syndrome can be included in early phase clinical trials- a report from the T2016-003 Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) study","year":2023,"lang":"en","type":"letter","venue":"Leukemia","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Childhood leukemia; Clinical trial; Lymphoma; Leukemia; Oncology; Internal medicine; Pediatrics; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005939974,0.0005583474,0.001053387,0.0002924686,0.00111832,0.00250586,0.0009001181,0.01843423,0.005071729],"category_scores_gemma":[0.01730934,0.0003978308,0.001114818,0.0005462871,0.000937667,0.001673762,0.0009177435,0.01186489,0.003012945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001924052,"about_ca_system_score_gemma":0.002688885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002074318,"about_ca_topic_score_gemma":0.006983182,"domain_scores_codex":[0.9962489,0.001812128,0.0003929523,0.000244797,0.0007956509,0.0005055018],"domain_scores_gemma":[0.9872392,0.008478473,0.0008890335,0.000286978,0.0007919826,0.00231425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.003076195,0.0002496876,0.00854666,0.0002422554,0.0001259804,0.006349131,0.0001300833,0.0004329902,0.002250455,0.005293047,0.8668019,0.1065015],"study_design_scores_gemma":[0.003577129,0.001016922,0.008342415,0.0004158468,0.0001806365,0.005639657,0.0001761866,0.001185644,0.00145262,0.01108197,0.9668724,0.00005864387],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.00675263,0.006562746,0.0005149932,0.9607524,0.009876391,0.00008222139,0.000626381,0.00006852357,0.01476376],"genre_scores_gemma":[0.05240221,0.00828026,0.001919868,0.8899345,0.03217565,0.000264091,0.000746149,0.00008295313,0.01419436],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01843423,"threshold_uncertainty_score":0.03141397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849077058438214,"score_gpt":0.3727920895735582,"score_spread":0.3243013189891761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}