{"id":"W4321491185","doi":"10.7554/elife.82705.sa2","title":"Author response: Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Head and neck squamous-cell carcinoma; Tumor microenvironment; Cancer research; Cancer; CD8; Cell; Medicine; Head and neck cancer; Oncology; Antigen; Internal medicine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004036588,0.0004089825,0.0006261909,0.001017753,0.0008060699,0.002223745,0.001051873,0.003648813,0.1424213],"category_scores_gemma":[0.03183726,0.000227049,0.0004269923,0.0004595402,0.0006828334,0.001551475,0.001231284,0.002194797,0.04446657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009184578,"about_ca_system_score_gemma":0.002636102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000830944,"about_ca_topic_score_gemma":0.002260556,"domain_scores_codex":[0.9970566,0.0008608408,0.0002341127,0.0003782763,0.001195922,0.0002741449],"domain_scores_gemma":[0.9743134,0.005219208,0.001324526,0.0007461763,0.01562343,0.002773245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000256933,0.00003010936,0.0005045849,0.0006364087,0.00002134457,0.000116534,0.00006523232,0.0000506534,0.0005187912,0.0003017797,0.9618343,0.03566324],"study_design_scores_gemma":[0.0001858535,0.000188633,0.002745119,0.0005686703,0.00003860141,0.0003836278,0.0004409658,0.0001479187,0.001161921,0.001455793,0.9926536,0.00002936041],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008039306,0.0216489,0.001576648,0.5595741,0.3631121,0.0005471022,0.003728576,0.000810581,0.04096271],"genre_scores_gemma":[0.06132817,0.02812016,0.002271082,0.1882756,0.1645329,0.00039331,0.003349864,0.0007316434,0.5509972],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1424213,"threshold_uncertainty_score":0.4764466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0342362463090908,"score_gpt":0.3318167220776942,"score_spread":0.2975804757686035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}