{"id":"W4321493200","doi":"10.1021/acschembio.3c00035","title":"Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Ralph W. and Grace M. Showalter Research Trust Fund; Sapienza Università di Roma; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Moiety; Methyltransferase; Stereochemistry; Adenosine; Chemistry; Ribose; Methylation; DNA; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982885,0.000266636,0.0006126636,0.0001607931,0.00003748818,0.000005192946,0.0001786313,0.0002991465,0.00001836141],"category_scores_gemma":[0.0001048059,0.0002402142,0.00009806632,0.0005557453,0.0003983921,0.000005728241,0.00009741338,0.0001622191,0.000003237839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612356,"about_ca_system_score_gemma":0.00005398789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007578409,"about_ca_topic_score_gemma":0.00002310991,"domain_scores_codex":[0.9982408,0.0001784397,0.0006018674,0.0005535471,0.0001492283,0.0002761548],"domain_scores_gemma":[0.9991662,0.0001122838,0.0001461428,0.0003211173,0.0001607942,0.00009345651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006748673,0.0003443247,0.001014209,0.00003764627,0.000247889,0.000002512508,0.0003562956,0.00005076429,0.9956115,0.00005951017,0.0002302362,0.001370283],"study_design_scores_gemma":[0.002072351,0.0020401,0.0007457462,0.00003305875,0.00007137638,0.000008689272,0.0004516063,0.00001441741,0.9934698,0.0001264567,0.0007458546,0.0002205147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962679,0.002452393,0.00007293341,0.0001864975,0.00006329241,0.0007683345,0.0001160853,0.00002913279,0.00004346483],"genre_scores_gemma":[0.9986085,0.0004607869,0.0001019054,0.00001392512,0.0001363036,0.000080059,0.0005342626,0.00002308271,0.00004114629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340662,"threshold_uncertainty_score":0.979565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715073806392867,"score_gpt":0.281222284718386,"score_spread":0.2640715466544573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}