{"id":"W4321493200","doi":"10.1021/acschembio.3c00035","title":"Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a <i>Clostridioides difficile-</i>Specific DNA Adenine Methyltransferase","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Ralph W. and Grace M. Showalter Research Trust Fund; Sapienza Università di Roma; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Moiety; Methyltransferase; Stereochemistry; Adenosine; Chemistry; Ribose; Methylation; DNA; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192373,0.0002837846,0.0002370501,0.0001752237,0.00007306312,0.0001307774,0.000245376,0.0002024608,0.0010744],"category_scores_gemma":[0.00008641284,0.0001040402,0.0002243905,0.00014458,0.00006036463,0.0001315702,0.00007965585,0.0002276266,0.0002070114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001605458,"about_ca_system_score_gemma":0.0001131102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005343365,"about_ca_topic_score_gemma":0.0008554046,"domain_scores_codex":[0.9999185,0.00001762291,0.000007305041,0.00001673152,0.00001968554,0.00002019005],"domain_scores_gemma":[0.9999447,0.00001306777,0.00001371349,0.000004209253,0.00001028811,0.00001407261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003761281,0.0001438544,0.0001030525,0.0001045537,0.00001970362,0.00006525972,0.00001173765,0.00042028,0.9931809,0.00008005807,0.0000684615,0.005425925],"study_design_scores_gemma":[0.00007056791,0.004319055,0.001533494,0.000008006346,0.00004651989,0.0001960257,0.00001542885,0.001503763,0.9884413,0.00002231533,0.003832919,0.0000105765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986819,0.006878379,0.001988702,0.00009067277,0.00004382651,0.00006054284,0.000326585,0.00006330957,0.003728965],"genre_scores_gemma":[0.9903212,0.002864861,0.003832922,0.00005408243,0.00001753577,0.00003148174,0.0004828801,0.00001382322,0.002381157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010744,"threshold_uncertainty_score":0.00359422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715073806392867,"score_gpt":0.281222284718386,"score_spread":0.2640715466544573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}