{"id":"W4321495254","doi":"10.1128/aem.01880-22","title":"Capacity of a Microbial Synbiotic To Rescue the <i>In Vitro</i> Metabolic Activity of the Gut Microbiome following Perturbation with Alcohol or Antibiotics","year":2023,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Wageningen University and Research","keywords":"Microbiome; Dysbiosis; Biology; Gut flora; Microbiology; Prebiotic; Faecalibacterium prausnitzii; Butyrate; Human microbiome; Antibiotics; Bifidobacterium; Synbiotics; Probiotic; Bacteria; Feces; Food science; Biochemistry; Lactobacillus; Bioinformatics; Fermentation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478998,0.0003702946,0.0003235817,0.0001350811,0.0001077217,0.0002696688,0.0002313864,0.0002912998,0.001076109],"category_scores_gemma":[0.0001554388,0.0001170405,0.0003215217,0.0001004163,0.0001967713,0.0001882549,0.0003325389,0.0005048246,0.0002693805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612359,"about_ca_system_score_gemma":0.0002929893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005705424,"about_ca_topic_score_gemma":0.0007930539,"domain_scores_codex":[0.9998717,0.00002519089,0.00001072717,0.00002860334,0.00003674076,0.00002701207],"domain_scores_gemma":[0.999858,0.00001856273,0.00004745591,0.00002036622,0.00001841374,0.00003729293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489694,0.00003120857,0.0001058759,0.00003755938,0.000006411914,0.00001609296,0.000006277561,0.0001027315,0.9987249,0.00002339486,0.00001990463,0.0007766675],"study_design_scores_gemma":[0.00001792475,0.001212239,0.003227224,0.00001374577,0.00002847896,0.00006804067,0.00004144671,0.001301266,0.9923398,0.00007095192,0.001670173,0.000008547257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919819,0.001372875,0.004422755,0.0001498098,0.00009601715,0.00005775202,0.0005760979,0.0000775528,0.001265221],"genre_scores_gemma":[0.9939213,0.0007767876,0.003296887,0.0001065167,0.00001092429,0.00006555711,0.0005401071,0.00002905585,0.001252803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076109,"threshold_uncertainty_score":0.003599942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009299013830568947,"score_gpt":0.2111347778502434,"score_spread":0.2018357640196744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}