{"id":"W4321500387","doi":"10.7554/elife.82705","title":"Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Health Department of Sichuan Province; Sichuan University; West China Hospital, Sichuan University; Department of Science and Technology of Sichuan Province; Sichuan Province Science and Technology Support Program; National Youth Foundation of China; China Postdoctoral Science Foundation","keywords":"Head and neck squamous-cell carcinoma; Cancer research; CD8; Cell; Cancer; Biology; Antigen; Medicine; Immunology; Head and neck cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000962575,0.0001592395,0.0002266553,0.0001921577,0.0001504638,0.0002863251,0.00007027169,0.000167852,0.001241034],"category_scores_gemma":[0.0001347529,0.0001020666,0.000147652,0.0001024724,0.0001465858,0.0001973511,0.0002244829,0.0003785136,0.0001373531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571865,"about_ca_system_score_gemma":0.0001441358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002832305,"about_ca_topic_score_gemma":0.0005644974,"domain_scores_codex":[0.9999171,0.00001043247,0.00000484325,0.00001924921,0.00001544699,0.00003283021],"domain_scores_gemma":[0.9999524,0.000006047594,0.00001122538,0.000003851248,0.000007161629,0.00001927976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009704543,0.000153519,0.02082803,0.000138572,0.00003940037,0.0003019435,0.00008649909,0.0003788766,0.9602854,0.0001136094,0.0003849089,0.01631884],"study_design_scores_gemma":[0.0001521811,0.003307757,0.5506477,0.0000541894,0.0001565906,0.001597596,0.001067431,0.003934007,0.42753,0.000739247,0.01079091,0.00002232433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981868,0.0009798731,0.0002464497,0.00004202075,0.00001039685,0.00001082115,0.0001099792,0.0000184503,0.0003952998],"genre_scores_gemma":[0.9982142,0.0003602277,0.0003028378,0.00008779635,0.000009641039,0.00001997217,0.0002009253,0.00000489074,0.000799497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241034,"threshold_uncertainty_score":0.004151642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161420697863917,"score_gpt":0.2762301884715075,"score_spread":0.2600881186851158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}