{"id":"W4321503000","doi":"10.1016/j.jacig.2023.100087","title":"Successful use of lanadelumab in a patient with hereditary angioedema with normal C1 inhibitor and negative genetic testing","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology Global","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Takeda Canada; CSL Behring","keywords":"Hereditary angioedema; Angioedema; C1-inhibitor; Kallikrein; Medicine; Dermatology; Pathophysiology; Internal medicine; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338309,0.0004994193,0.0005583304,0.0006402453,0.0007353286,0.0003093495,0.0003335785,0.00100062,0.0007839907],"category_scores_gemma":[0.001211741,0.0001612306,0.000560476,0.0002337022,0.0003830047,0.0004889069,0.0003938811,0.001136577,0.0003292792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010609,"about_ca_system_score_gemma":0.00041127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121908,"about_ca_topic_score_gemma":0.001954613,"domain_scores_codex":[0.9997491,0.00004566214,0.00002537345,0.00006830216,0.00005267658,0.00005880007],"domain_scores_gemma":[0.9995883,0.0001408988,0.00005622243,0.00003398026,0.0000409352,0.0001395488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001066924,0.001309796,0.04358612,0.000304403,0.0001880687,0.7823282,0.0007575841,0.0006820389,0.04053621,0.0004585622,0.003218433,0.1255636],"study_design_scores_gemma":[0.0001892995,0.004467391,0.04976827,0.00007775765,0.0001823904,0.9203831,0.0001759986,0.001390898,0.01481012,0.0003023823,0.008190906,0.00006147131],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604075,0.009902841,0.004789571,0.006000191,0.0003929878,0.000313489,0.0001770573,0.0003744901,0.01764178],"genre_scores_gemma":[0.9947492,0.001151362,0.001373473,0.001062735,0.0001508932,0.00003083047,0.00007049361,0.00002171749,0.001389361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121908,"threshold_uncertainty_score":0.003635526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02849111183741568,"score_gpt":0.2870347758266666,"score_spread":0.2585436639892509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}