{"id":"W4321503018","doi":"10.1016/j.mbplus.2023.100129","title":"Single collagen fibrils isolated from high stress and low stress tendons show differing susceptibility to enzymatic degradation by the interstitial collagenase matrix metalloproteinase-1 (MMP-1)","year":2023,"lang":"en","type":"article","venue":"Matrix Biology Plus","topic":"Tendon Structure and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Mary's University; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Dalhousie University","keywords":"Fibril; Collagen fibril; Tendon; Biophysics; Chemistry; Matrix metalloproteinase; Collagenase; Matrix (chemical analysis); Extracellular matrix; Anatomy; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276277,0.0003501112,0.0006136944,0.0001514266,0.000221756,0.00007220857,0.0001723213,0.0002163642,0.0002032013],"category_scores_gemma":[0.0001550917,0.0002313682,0.000110061,0.0004378827,0.0001797879,0.00006054849,0.0002111807,0.000134099,0.00006319723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259273,"about_ca_system_score_gemma":0.00007236721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001703166,"about_ca_topic_score_gemma":0.0009500253,"domain_scores_codex":[0.9981096,0.0002062453,0.0004293275,0.0006065405,0.0001810923,0.00046713],"domain_scores_gemma":[0.998658,0.0003749045,0.0001360031,0.0005344384,0.00007728556,0.000219357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00243727,0.0003520736,0.02424386,0.0004950009,0.001456728,0.0004572021,0.002005107,0.0001922731,0.9539338,0.0001794016,0.002957741,0.01128949],"study_design_scores_gemma":[0.025947,0.007333023,0.1111878,0.001296865,0.003701715,0.0003656382,0.007405149,0.009594796,0.8242725,0.001519287,0.004980152,0.002396121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929612,0.0006792618,0.0005554778,0.00167937,0.0003313714,0.00111338,0.002406546,0.0002347506,0.00003858878],"genre_scores_gemma":[0.9958908,0.0000449451,0.0004927532,0.0001189399,0.0001484121,0.0001257913,0.001878283,0.00003604033,0.001264066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1296614,"threshold_uncertainty_score":0.9434923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538263893571458,"score_gpt":0.2776923601985813,"score_spread":0.2623097212628667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}