{"id":"W4321597001","doi":"10.1002/ijc.34478","title":"An integrated multiomics analysis of rectal cancer patients identified <scp>POU2F3</scp> as a putative druggable target and entinostat as a cytotoxic enhancer of 5‐fluorouracil","year":2023,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Discovery Centre; University Health Network","funders":"Regione del Veneto; Associazione Italiana per la Ricerca sul Cancro; Università degli Studi di Padova; Canada Foundation for Innovation; Fondazione Cassa di Risparmio di Padova e Rovigo","keywords":"Medicine; Colorectal cancer; Oncology; Histone deacetylase inhibitor; Cancer research; Cancer; Internal medicine; microRNA; Bioinformatics; Histone deacetylase; Gene; Histone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002733339,0.0004262656,0.0006561049,0.001023281,0.0002968767,0.000415834,0.0001963097,0.0002609432,0.0009787341],"category_scores_gemma":[0.0003984424,0.0001217691,0.0009240704,0.0011726,0.0001160529,0.0002084317,0.0004278664,0.0002851161,0.0002094928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004067384,"about_ca_system_score_gemma":0.0004429665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004071847,"about_ca_topic_score_gemma":0.005586724,"domain_scores_codex":[0.9998229,0.00002530908,0.00000974264,0.00007366292,0.00002586746,0.00004244754],"domain_scores_gemma":[0.9998585,0.00003020879,0.00004165454,0.00001036646,0.00002746368,0.00003192815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002613455,0.0003283302,0.8338786,0.0004422523,0.001702677,0.0009452078,0.0001786028,0.007773188,0.07319449,0.0004001029,0.004488294,0.07405476],"study_design_scores_gemma":[0.00006626968,0.0005546323,0.9318577,0.00003865145,0.0008560879,0.001104359,0.0002687173,0.05082932,0.008754664,0.000844555,0.004783021,0.00004198733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985361,0.001148104,0.003279326,0.000189988,0.00002023688,0.00003835987,0.009269502,0.0001217474,0.0005717411],"genre_scores_gemma":[0.9821963,0.0004275834,0.00331567,0.00009578637,0.00001637874,0.00005020644,0.01344191,0.0000180863,0.0004380674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004071847,"threshold_uncertainty_score":0.008096278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275416470372329,"score_gpt":0.3512276153150445,"score_spread":0.3384734506113213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}