{"id":"W4321598971","doi":"10.3390/ijms24054357","title":"CsgI (YccT) Is a Novel Inhibitor of Curli Fimbriae Formation in Escherichia coli Preventing CsgA Polymerization and Curli Gene Expression","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; National Centre for Biological Sciences; Japan Society for the Promotion of Science; Directorate for Biological Sciences; Jikei University School of Medicine","keywords":"Fimbria; Biofilm; Periplasmic space; Escherichia coli; Cell biology; Biology; rpoS; Operon; Pilus; Microbiology; Gene; Gene expression; Bacteria; Biochemistry; Promoter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338562,0.0007467075,0.0005050275,0.0002805793,0.0001250031,0.0002615035,0.0004339321,0.0003483862,0.0008154942],"category_scores_gemma":[0.000112247,0.000202454,0.0004129014,0.0002872323,0.0002516576,0.0001289887,0.0001961613,0.0007392879,0.0003211061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617126,"about_ca_system_score_gemma":0.0004945417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428009,"about_ca_topic_score_gemma":0.001668857,"domain_scores_codex":[0.9998337,0.00002454936,0.00002065269,0.00002684699,0.00005904776,0.00003520946],"domain_scores_gemma":[0.9998822,0.00002308551,0.00003317254,0.00001314004,0.00001707601,0.00003131995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008971749,0.00004618993,0.00005354212,0.00004622333,0.000008370788,0.00002848633,0.000004189929,0.00007881501,0.9983526,0.00004001215,0.00005559679,0.001196265],"study_design_scores_gemma":[0.00006046424,0.0003312148,0.001105852,0.000006114153,0.00001797615,0.0001632682,0.000004551047,0.0007089608,0.9952844,0.000008780609,0.002302638,0.000005760436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796059,0.006760004,0.009911105,0.0002499669,0.00008710982,0.0002106483,0.0009200798,0.0005406913,0.001714485],"genre_scores_gemma":[0.9820325,0.002721552,0.009923392,0.0001318162,0.00002496829,0.00017064,0.001849934,0.00008621995,0.003059016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428009,"threshold_uncertainty_score":0.00334996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334603636058951,"score_gpt":0.2684763156953545,"score_spread":0.255130279334765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}