{"id":"W4321601068","doi":"10.3389/fimmu.2023.1125960","title":"Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A)","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Calgary Firefighters Burn Treatment Society; Alberta Innovates; Killam Trusts","keywords":"Medicine; Immunology; Autoantibody; Immune system; Etiology; Coronavirus disease 2019 (COVID-19); Immune dysregulation; Inflammation; Systemic inflammatory response syndrome; Disease; Infectious disease (medical specialty); Antibody; Pathology; Sepsis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002721173,0.000711348,0.0005889101,0.001292011,0.001006488,0.0009445821,0.000582327,0.002637017,0.001691734],"category_scores_gemma":[0.00107679,0.0004622853,0.0004371838,0.0005954709,0.0007989423,0.0008465891,0.0009972639,0.00167199,0.0005653671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005572917,"about_ca_system_score_gemma":0.0003540844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001463923,"about_ca_topic_score_gemma":0.001657764,"domain_scores_codex":[0.9996494,0.00004066567,0.00003099469,0.0001224955,0.00004910716,0.0001073027],"domain_scores_gemma":[0.9995131,0.0001110447,0.00009277429,0.00006030258,0.00004024549,0.0001823933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00012647,0.00005604953,0.03907117,0.00004586712,0.00001929021,0.9512641,0.0004478633,0.00009849305,0.004495339,0.0003555617,0.0006840885,0.00333559],"study_design_scores_gemma":[0.000007910039,0.0000870055,0.01633953,0.00001789305,0.00001627241,0.9809853,0.000182288,0.0003153383,0.001029466,0.0002107479,0.0007973303,0.00001090956],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827415,0.002382607,0.004797901,0.002578756,0.0001394578,0.0001724008,0.000412878,0.0001610346,0.006613424],"genre_scores_gemma":[0.9964725,0.000559405,0.001538175,0.0005128842,0.0001973614,0.0000162406,0.00009432404,0.00001257913,0.0005966494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637017,"threshold_uncertainty_score":0.005659401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013031331192918,"score_gpt":0.2490528439176634,"score_spread":0.2389225306057342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}