{"id":"W4321604757","doi":"10.21203/rs.3.rs-2605378/v1","title":"Ankrd11, a chromatin regulator and a KBG syndrome risk gene, is a critical regulator of cardiac neural crest cell biology and heart development","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Vetenskapsrådet; Austrian Science Fund; University of Alberta; Knut och Alice Wallenbergs Stiftelse; Core Research for Evolutional Science and Technology; Göran Gustafssons Stiftelser","keywords":"Neural crest; Biology; Regulator; Heart development; Truncus arteriosus; Cell biology; Embryonic stem cell; Genetics; Internal medicine; Gene; Heart disease; Medicine; Tetralogy of Fallot; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833241,0.0005477424,0.0004169314,0.0003045271,0.0002945704,0.0005624764,0.0003666007,0.0006600897,0.003253056],"category_scores_gemma":[0.0004612115,0.0003242182,0.0002238164,0.0002240486,0.0003737205,0.0002025773,0.0004146006,0.0007865112,0.001246935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002963205,"about_ca_system_score_gemma":0.0002361782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007182375,"about_ca_topic_score_gemma":0.0009634767,"domain_scores_codex":[0.9997731,0.00002495267,0.00001573169,0.0000883241,0.00007138359,0.00002656532],"domain_scores_gemma":[0.9997886,0.00006044306,0.00005919467,0.00002497944,0.00001548658,0.00005125056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005152202,0.00001664562,0.004038758,0.0001075591,0.00004279898,0.00213196,0.00003765287,0.0006490807,0.9821399,0.0009153811,0.0009981677,0.008406782],"study_design_scores_gemma":[0.0001931839,0.0002078113,0.1060907,0.00005135734,0.000217704,0.01181254,0.0001259796,0.007394156,0.8425975,0.002296788,0.02896574,0.0000465758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458898,0.006309594,0.03182663,0.0008845362,0.0004274029,0.00004043782,0.004391172,0.001104447,0.009125971],"genre_scores_gemma":[0.9771589,0.001076694,0.007396606,0.0001252103,0.00005983777,0.00002983362,0.004231471,0.0001909815,0.009730429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003253056,"threshold_uncertainty_score":0.0108825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03989880737258514,"score_gpt":0.3830554817345618,"score_spread":0.3431566743619767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}