{"id":"W4321604791","doi":"10.1101/2023.02.23.529741","title":"Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta","funders":"National Institutes of Health; Manpei Suzuki Diabetes Foundation; University of British Columbia; BC Children's Hospital; Juvenile Diabetes Research Foundation Canada","keywords":"Human leukocyte antigen; Graft-versus-host disease; Host (biology); Islet; Human disease; Immunology; Disease; Biology; Medicine; Diabetes mellitus; Antigen; Genetics; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003575507,0.0005457969,0.0004015878,0.00019143,0.0001073483,0.0004534212,0.0001712731,0.0005084957,0.001991292],"category_scores_gemma":[0.0001762532,0.0001459554,0.0003063085,0.0001075378,0.000218727,0.0002705689,0.0001783529,0.0009115109,0.000446071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481892,"about_ca_system_score_gemma":0.0001798184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003857533,"about_ca_topic_score_gemma":0.0002653355,"domain_scores_codex":[0.9996519,0.00005957966,0.00003406447,0.0001035527,0.00006085955,0.00008996741],"domain_scores_gemma":[0.9997699,0.00005908798,0.00004107447,0.00005011285,0.00002048031,0.00005931155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005110323,0.000171301,0.0002116102,0.00003004585,0.00001224382,0.00004284837,0.00002616814,0.0001260419,0.9975344,0.00006247329,0.00007785633,0.00119406],"study_design_scores_gemma":[0.0000945216,0.003187442,0.002384014,0.00001092598,0.00003370577,0.0002867732,0.00004395948,0.002412473,0.9895801,0.00005339091,0.001905487,0.000007281651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954976,0.0006901146,0.002338762,0.0000432845,0.00006711224,0.00003355329,0.0002220773,0.0001268241,0.0009807298],"genre_scores_gemma":[0.9948521,0.0002956213,0.001512222,0.0001002333,0.00002957178,0.00005504552,0.0003713437,0.00003760098,0.002746333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991292,"threshold_uncertainty_score":0.006661594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04115098003091187,"score_gpt":0.3020467307956627,"score_spread":0.2608957507647508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}