{"id":"W4321605214","doi":"10.2147/ndt.s388392","title":"Early Clinical Experiences of Esketamine Nasal Spray in the UK in Adults with Treatment-Resistant Major Depressive Disorder: Advisory Panel Recommendations","year":2023,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Treatment of Major Depression","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Victoria General Hospital Foundation; H. Lundbeck A/S; Servier; National Institute for Health and Care Research; National Institute of Mental Health; University of Surrey; LivaNova; Wellcome Trust; Canadian Institutes of Health Research; Sunovion; Michael Smith Health Research BC; Eli Lilly and Company; AstraZeneca; National Alliance for Research on Schizophrenia and Depression; South London and Maudsley NHS Foundation Trust; Medical Research Council; Biogen; King's College London","keywords":"Medicine; Discontinuation; Nasal spray; Major depressive disorder; Intensive care medicine; Depression (economics); Family medicine; Psychiatry; Nasal administration; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06112989,0.0008574013,0.001135741,0.0009844881,0.004660148,0.005394423,0.004129599,0.02312323,0.01384754],"category_scores_gemma":[0.1513017,0.0009493133,0.003287145,0.001746219,0.001601279,0.004290245,0.004417844,0.01493037,0.00593703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005904639,"about_ca_system_score_gemma":0.02499222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01705286,"about_ca_topic_score_gemma":0.03844921,"domain_scores_codex":[0.9438316,0.03025326,0.01162699,0.001775149,0.008173338,0.004339683],"domain_scores_gemma":[0.7947847,0.06883829,0.01522258,0.003727291,0.08822402,0.02920309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0001689237,0.0001307591,0.002469114,0.002409629,0.00005923978,0.0005214546,0.0009979826,0.0001330901,0.0004576807,0.0005900515,0.9207479,0.07131433],"study_design_scores_gemma":[0.0003244835,0.0004134228,0.009810329,0.01376011,0.0001555873,0.0004721851,0.003445862,0.0002745773,0.0002942079,0.001313401,0.9695926,0.0001431292],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003307347,0.0127982,0.0009049138,0.9333621,0.02445765,0.001812633,0.000728823,0.0001399259,0.02248839],"genre_scores_gemma":[0.06766227,0.0614491,0.02273113,0.7663647,0.0314834,0.006603298,0.002741667,0.0003070968,0.0406574],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06112989,"threshold_uncertainty_score":0.3232897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723356087096858,"score_gpt":0.3048561568947888,"score_spread":0.2776225960238202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}