{"id":"W4321606354","doi":"10.1016/s2213-2600(23)00001-2","title":"A new triple combination cystic fibrosis transmembrane regulator modulator","year":2023,"lang":"en","type":"letter","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Medicine; Regulator; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Transmembrane protein; Computational biology; Internal medicine; Genetics; Receptor; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002778774,0.001047139,0.001719215,0.0007020771,0.001835526,0.002974367,0.001121156,0.03090616,0.007044481],"category_scores_gemma":[0.01182067,0.0005150101,0.001741213,0.0003653963,0.001914168,0.003275795,0.001331816,0.03190484,0.005396148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002730171,"about_ca_system_score_gemma":0.001579977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328395,"about_ca_topic_score_gemma":0.004111858,"domain_scores_codex":[0.9974977,0.0006460219,0.000251416,0.0003495462,0.0008954793,0.000359738],"domain_scores_gemma":[0.9958631,0.002578764,0.0002640089,0.0001264814,0.0003776723,0.0007900514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004135727,0.0001173216,0.0005086333,0.0001775463,0.00005400287,0.004016917,0.00009948583,0.0002346948,0.0009329872,0.00931837,0.9314831,0.05264327],"study_design_scores_gemma":[0.0009520673,0.000448972,0.0007764746,0.0003838696,0.0000670278,0.002499372,0.0001475932,0.0007130314,0.0004654587,0.01981891,0.9736673,0.00005983813],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.001022492,0.01300208,0.0003842429,0.929173,0.04826059,0.00002927039,0.0001320309,0.00005811045,0.007938066],"genre_scores_gemma":[0.01009689,0.00601289,0.0005990813,0.8945308,0.07486562,0.00009214309,0.00008522818,0.00003529436,0.01368212],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.03090616,"threshold_uncertainty_score":0.02356619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972740929424565,"score_gpt":0.3343855135326457,"score_spread":0.2746581042384001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}