{"id":"W4321606773","doi":"10.1002/gepi.22521","title":"Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes","year":2023,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Medical School, University of Michigan; National Institutes of Health; Institut de Valorisation des Données; Northwest Regional Development Agency; Dr. Robert C. and Veronica Atkins Foundation; Cancer Research UK; British Heart Foundation; Wellcome Trust; University of Michigan; Juvenile Diabetes Research Foundation United States of America; National Institute of Diabetes and Digestive and Kidney Diseases; A. Alfred Taubman Medical Research Institute; Alliance de recherche numérique du Canada; U.S. Department of Veterans Affairs","keywords":"Genome-wide association study; Type 2 diabetes; Single-nucleotide polymorphism; Biobank; Receiver operating characteristic; Genotype; Genetic association; Biology; Genetics; Type 1 diabetes; Medicine; Diabetes mellitus; Internal medicine; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01669418,0.001870356,0.001156309,0.003617744,0.0006490629,0.002354601,0.001045751,0.001068949,0.002632305],"category_scores_gemma":[0.03454437,0.0003994537,0.002873438,0.002218869,0.0007395687,0.0008788305,0.001645735,0.001589182,0.0005843878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007934266,"about_ca_system_score_gemma":0.0008882996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008621537,"about_ca_topic_score_gemma":0.005651735,"domain_scores_codex":[0.9926677,0.004851542,0.0003946132,0.001084614,0.0006477832,0.0003537169],"domain_scores_gemma":[0.9727508,0.02157458,0.001988149,0.001721161,0.001382679,0.0005825688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001987671,0.0003774566,0.814073,0.0001393899,0.003720073,0.0005314181,0.0004400349,0.0985963,0.002019162,0.003369518,0.002709086,0.07203685],"study_design_scores_gemma":[0.000134254,0.0008595843,0.2305517,0.00008455933,0.0007300626,0.0007984777,0.0002060884,0.7564816,0.001091072,0.007367727,0.001586609,0.0001082409],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8869349,0.0009518611,0.1050727,0.000595384,0.00007300841,0.0002313528,0.002467592,0.0007532822,0.002919978],"genre_scores_gemma":[0.9749765,0.0001277545,0.02248358,0.00009617263,0.00002483825,0.00007382311,0.001653059,0.0000778644,0.0004864115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01669418,"threshold_uncertainty_score":0.08828831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06528056570552886,"score_gpt":0.348363827924438,"score_spread":0.2830832622189092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}