{"id":"W4321606773","doi":"10.1002/gepi.22521","title":"Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes","year":2023,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Medical School, University of Michigan; National Institutes of Health; Institut de Valorisation des Données; Northwest Regional Development Agency; Dr. Robert C. and Veronica Atkins Foundation; Cancer Research UK; British Heart Foundation; Wellcome Trust; University of Michigan; Juvenile Diabetes Research Foundation United States of America; National Institute of Diabetes and Digestive and Kidney Diseases; A. Alfred Taubman Medical Research Institute; Alliance de recherche numérique du Canada; U.S. Department of Veterans Affairs","keywords":"Genome-wide association study; Type 2 diabetes; Single-nucleotide polymorphism; Biobank; Receiver operating characteristic; Genotype; Genetic association; Biology; Genetics; Type 1 diabetes; Medicine; Diabetes mellitus; Internal medicine; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004370605,0.0001802219,0.0004917159,0.0001399138,0.00008693625,0.000003063653,0.0001833087,0.0002871771,0.00003892288],"category_scores_gemma":[0.01132643,0.0001656802,0.00006996886,0.0003979196,0.0001221691,0.000001483112,0.0002340985,0.0000962895,0.00007525059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001730853,"about_ca_system_score_gemma":0.0001158805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007645588,"about_ca_topic_score_gemma":0.00006952351,"domain_scores_codex":[0.9965826,0.001689608,0.000582756,0.0005033254,0.0001475863,0.0004941221],"domain_scores_gemma":[0.9982095,0.0004777385,0.0002797463,0.0004247714,0.0004631476,0.0001450716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001329414,0.000009118063,0.9539247,0.000008964256,0.0001805345,8.482827e-8,0.00003301163,0.001789368,0.01478564,0.00001453487,0.003494239,0.02574653],"study_design_scores_gemma":[0.0003061331,0.0005584409,0.9894131,0.000007949366,0.0002441979,9.033241e-7,0.00002235678,0.00198392,0.00114353,0.005309679,0.0008496296,0.0001600937],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946504,0.003487017,0.0006430331,0.0004416491,0.0003327448,0.0003038922,0.00004463555,0.00001927443,0.0000773046],"genre_scores_gemma":[0.9938992,0.001792182,0.00343126,0.0002383708,0.0002501491,0.0000344004,0.0002206435,0.00002364021,0.00011021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03548848,"threshold_uncertainty_score":0.9970016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06528056570552886,"score_gpt":0.348363827924438,"score_spread":0.2830832622189092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}