{"id":"W4321611743","doi":"10.1093/neuonc/noad047","title":"The development of a rapid patient-derived xenograft model to predict chemotherapeutic drug sensitivity/resistance in malignant glial tumors","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Temozolomide; Carboplatin; Medicine; Glioma; Drug; Oncology; Drug resistance; Cancer research; Internal medicine; Pharmacology; Cisplatin; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003651872,0.0001961863,0.0004576685,0.0002006407,0.00011132,0.000008753608,0.00008911751,0.00007320476,0.00000786132],"category_scores_gemma":[0.0001245172,0.000139915,0.00008709897,0.0004877613,0.00008932289,0.00002508526,0.0001071659,0.0001456297,0.00003134705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375372,"about_ca_system_score_gemma":0.0004616393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001256331,"about_ca_topic_score_gemma":0.0008375596,"domain_scores_codex":[0.9981929,0.0001753287,0.0005205636,0.0003625588,0.0002941782,0.0004544437],"domain_scores_gemma":[0.9987932,0.0005367538,0.0001395817,0.0003022837,0.0000818382,0.0001463143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001027709,0.0008814528,0.005242193,0.00005390026,0.0001097952,0.0007134376,0.01024145,0.0006379782,0.9252971,0.00007916734,0.00196739,0.05374843],"study_design_scores_gemma":[0.007094083,0.001433704,0.04736302,0.000263103,0.0001206514,0.00005552782,0.001510615,0.007786025,0.9003593,0.0001633251,0.03351949,0.0003311888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923294,0.0001023243,0.00003943152,0.005891949,0.0001822324,0.0009762043,0.00001218687,0.00006696638,0.0003993177],"genre_scores_gemma":[0.9975256,0.00006666694,0.0009911559,0.001037119,0.00002957378,0.0002810126,0.00001225112,0.00003182964,0.0000247457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05341724,"threshold_uncertainty_score":0.5705568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511477343673941,"score_gpt":0.2794386244836101,"score_spread":0.2543238510468707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}