{"id":"W4321612257","doi":"10.1007/s00018-023-04700-3","title":"Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Research Foundation of Korea; Ministry of Science and ICT, South Korea; Ministry of Oceans and Fisheries; Korea Institute of Marine Science and Technology promotion; National Research Foundation","keywords":"Autophagy; mTORC1; Mitochondrion; PI3K/AKT/mTOR pathway; Biology; Mitophagy; Oxidative stress; Zebrafish; Peroxisome; Cell biology; Endocrinology; Internal medicine; Signal transduction; Apoptosis; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300404,0.0005919574,0.0002933619,0.0003904477,0.00023712,0.0002165593,0.0002947187,0.0005153352,0.002576926],"category_scores_gemma":[0.00009639905,0.0002421181,0.0004266853,0.00009149007,0.000378869,0.000244092,0.0003635672,0.0008203767,0.0003153404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005956608,"about_ca_system_score_gemma":0.0003215319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002220319,"about_ca_topic_score_gemma":0.004010495,"domain_scores_codex":[0.9998598,0.00001135072,0.00002191751,0.00004000306,0.00003533451,0.00003165314],"domain_scores_gemma":[0.9999025,0.000009932176,0.00003784806,0.00001017319,0.00001001215,0.00002943537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009913743,0.00001191857,0.000124276,0.00004312249,0.000004653234,0.00006498882,0.00001088043,0.00004382309,0.9989975,0.00007503997,0.00004643275,0.0004782737],"study_design_scores_gemma":[0.00003549435,0.0006269106,0.006384757,0.00002176974,0.00002911866,0.000263176,0.00006274569,0.0006306716,0.9897831,0.00007661407,0.002071162,0.00001441617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917343,0.001405361,0.003135716,0.0003224623,0.0001276969,0.00006826966,0.001117898,0.0002487533,0.001839662],"genre_scores_gemma":[0.9888599,0.001034187,0.002333612,0.0002082885,0.00001292175,0.0001260395,0.0007851265,0.00004405448,0.006595762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576926,"threshold_uncertainty_score":0.00862062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001098411338418,"score_gpt":0.2408112431041995,"score_spread":0.2308002589908154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}