{"id":"W4321612641","doi":"10.1128/spectrum.02550-22","title":"The Histone Variant H2A.Z C-Terminal Domain Has Locus-Specific Differential Effects on H2A.Z Occupancy and Nucleosome Localization","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Nucleosome; Histone; Genetics; Histone H2A; Effector; Gene; Locus (genetics); Biology; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121976,0.000210518,0.0001308758,0.0001036399,0.0001138039,0.000239397,0.0002364384,0.0001958591,0.001127108],"category_scores_gemma":[0.00009216354,0.0001204617,0.0002428878,0.0001341482,0.0003755379,0.0001248982,0.0001937476,0.0004081017,0.0002165534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923222,"about_ca_system_score_gemma":0.0002167599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011011,"about_ca_topic_score_gemma":0.001626086,"domain_scores_codex":[0.9999044,0.00001177891,0.000007077556,0.00002930632,0.00001803799,0.00002942293],"domain_scores_gemma":[0.9998814,0.00002353682,0.00002351507,0.000014889,0.000008332538,0.00004835861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009784383,0.000007693877,0.0001390022,0.000006662243,0.000002665516,0.0000116819,0.0000026949,0.00001473081,0.9994649,0.00004530394,0.000005705577,0.0002012354],"study_design_scores_gemma":[0.00001332308,0.000107101,0.005890191,0.000001369252,0.00001172857,0.0001453597,0.00001376065,0.0003210646,0.9928349,0.00001965652,0.000638767,0.000002825379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974624,0.000375146,0.001333709,0.00004089527,0.00001524648,0.000006851316,0.0001554653,0.00001794428,0.0005923524],"genre_scores_gemma":[0.9984125,0.0000947592,0.0005334177,0.00002289619,0.000002716786,0.000005814527,0.0002437619,0.00001001696,0.0006740417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127108,"threshold_uncertainty_score":0.00377053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004943470466884422,"score_gpt":0.2084187023308774,"score_spread":0.203475231863993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}