{"id":"W4321748193","doi":"10.1158/1078-0432.ccr-22-2955","title":"Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Advancing Translational Sciences; National Cancer Institute","keywords":"Medicine; Lymphoma; Follicular lymphoma; Angioimmunoblastic T-cell lymphoma; T cell; Internal medicine; Adverse effect; Oncology; Peripheral T-cell lymphoma; Refractory (planetary science); Pharmacodynamics; Gastroenterology; Immunology; Pharmacokinetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741476,0.0002077456,0.000396294,0.0001230937,0.0001341725,0.0002114637,0.0001826203,0.0001576452,0.0006311664],"category_scores_gemma":[0.0003111066,0.00008518714,0.000137642,0.0001699594,0.0001849818,0.0001622494,0.0001000709,0.0003573333,0.0001891375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894913,"about_ca_system_score_gemma":0.0002592655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003749561,"about_ca_topic_score_gemma":0.0009273907,"domain_scores_codex":[0.999925,0.0000265959,0.000007452822,0.0000110154,0.00001289978,0.00001697762],"domain_scores_gemma":[0.9998804,0.00003100446,0.00003198651,0.000008402577,0.000007669167,0.00004058084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04949116,0.003751314,0.4471793,0.0007912091,0.0004468611,0.004367999,0.0007373586,0.003625922,0.1663382,0.0003229508,0.002530181,0.3204175],"study_design_scores_gemma":[0.01520859,0.2137643,0.6879058,0.0001406316,0.001130738,0.01482206,0.0005325722,0.007055677,0.04532578,0.0003902175,0.01368652,0.00003714949],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982368,0.00100855,0.0001308216,0.00003645508,0.000003113146,0.00003884319,0.00004367428,0.00001332731,0.0004885421],"genre_scores_gemma":[0.9991366,0.0003313205,0.0002007333,0.00006076649,0.00001085858,0.00001926651,0.0001055179,0.000001536799,0.0001333452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006311664,"threshold_uncertainty_score":0.002111435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07551008948559883,"score_gpt":0.395376646050156,"score_spread":0.3198665565645571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}