{"id":"W4321749242","doi":"10.1242/dev.201227","title":"16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids","year":2023,"lang":"en","type":"article","venue":"Development","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Simons Initiative for the Developing Brain; University of Edinburgh; Wellcome Trust","keywords":"Biology; Organoid; Interneuron; NeuN; Induced pluripotent stem cell; Ganglionic eminence; Neuroscience; Neural stem cell; Progenitor cell; Cell biology; Stem cell; Inhibitory postsynaptic potential; Genetics; Embryonic stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528319,0.0002291612,0.0002157835,0.0002734668,0.0001072352,0.0002633239,0.0001576954,0.0002568901,0.001481613],"category_scores_gemma":[0.000141827,0.0001729986,0.0002513969,0.0001255174,0.0001496354,0.0001389538,0.0003287692,0.0004523562,0.0004890031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778214,"about_ca_system_score_gemma":0.0001556962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006167867,"about_ca_topic_score_gemma":0.0006908308,"domain_scores_codex":[0.999872,0.0000122699,0.0000210337,0.00003722761,0.00003734438,0.00002026838],"domain_scores_gemma":[0.9998922,0.00002580428,0.00002826626,0.00002141244,0.000009875622,0.00002243158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002643504,0.000006650253,0.0002700663,0.00001182887,0.000002724273,0.0001066494,0.00001519505,0.00006048074,0.9987075,0.00003002366,0.00002328383,0.0007391207],"study_design_scores_gemma":[0.000007760035,0.0001254703,0.01805787,0.000008614621,0.000019797,0.0009540871,0.00003973469,0.0007379236,0.9749157,0.00005390797,0.00507352,0.000005580507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929893,0.001038622,0.003303542,0.00005551592,0.00002623384,0.00002875128,0.0008810158,0.0000928594,0.001584216],"genre_scores_gemma":[0.9903138,0.0009310467,0.002023141,0.00003370613,0.000006189767,0.00005689242,0.002037573,0.00004969296,0.004547879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481613,"threshold_uncertainty_score":0.004956543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236695823440591,"score_gpt":0.2440068549939041,"score_spread":0.2316398967594982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}