{"id":"W4321749735","doi":"10.1093/brain/awad044","title":"Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Université de Montréal; Montreal General Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; McGill University; Hôpital du Sacré-Cœur de Montréal; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; National Institutes of Health; Parkinson Vereniging; H. Lundbeck A/S; Jascha Fonden; Électricité de France; Canadian Institutes of Health Research; Parkinson Canada; Lundbeckfonden; University of Waterloo; Agence Nationale de la Recherche; National Institute on Aging; Parkinsonforeningen; Institut de France; Medical Research Council; Biogen; Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Synucleinopathies; Neuroscience; Atrophy; Posterior cortical atrophy; Biology; Function (biology); Medicine; Parkinson's disease; Alpha-synuclein; Pathology; Dementia; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112555,0.0001490701,0.0002541521,0.0001832123,0.00008948677,0.00002072066,0.00004792655,0.0001104277,0.0001359467],"category_scores_gemma":[0.0002981359,0.0001314159,0.0001046008,0.0004884612,0.00004017897,0.00005135849,0.00003833419,0.0001305922,0.0005286135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099796,"about_ca_system_score_gemma":0.0001148693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004938464,"about_ca_topic_score_gemma":0.00007150508,"domain_scores_codex":[0.9987749,0.00008319179,0.0002068853,0.0003176776,0.0002795601,0.0003378164],"domain_scores_gemma":[0.9994889,0.0001005853,0.00004199063,0.0001821381,0.00003391795,0.0001523902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008363151,0.007732834,0.5179335,0.0004892849,0.002532417,0.01619708,0.001617522,0.0002125992,0.3055193,0.01323828,0.06562695,0.06053711],"study_design_scores_gemma":[0.005694159,0.0008148262,0.9812467,0.00009586616,0.0001791074,0.00002057857,0.0001659215,0.001027502,0.0008346495,0.001935465,0.007783679,0.0002015906],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996808,0.0001407728,0.0000584572,0.001379232,0.0004790121,0.0004156732,0.00002754162,0.0002498926,0.0004414272],"genre_scores_gemma":[0.9973785,0.00001917754,0.0001241166,0.0003680755,0.0001881385,0.00008084457,0.0001400475,0.00003103774,0.001670004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4633132,"threshold_uncertainty_score":0.6794434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068992915522647,"score_gpt":0.2629277764009063,"score_spread":0.2422378472456798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}