{"id":"W4321749735","doi":"10.1093/brain/awad044","title":"Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Université de Montréal; Montreal General Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; McGill University; Hôpital du Sacré-Cœur de Montréal; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; National Institutes of Health; Parkinson Vereniging; H. Lundbeck A/S; Jascha Fonden; Électricité de France; Canadian Institutes of Health Research; Parkinson Canada; Lundbeckfonden; University of Waterloo; Agence Nationale de la Recherche; National Institute on Aging; Parkinsonforeningen; Institut de France; Medical Research Council; Biogen; Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Synucleinopathies; Neuroscience; Atrophy; Posterior cortical atrophy; Biology; Function (biology); Medicine; Parkinson's disease; Alpha-synuclein; Pathology; Dementia; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556723,0.000381975,0.0003087888,0.000833274,0.0002981247,0.0002292663,0.0001772619,0.0001686147,0.001369752],"category_scores_gemma":[0.0004500701,0.0001499824,0.0002299237,0.0005939954,0.0003577882,0.0001108521,0.0002977441,0.0001781714,0.0001798924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157819,"about_ca_system_score_gemma":0.0001301309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00201224,"about_ca_topic_score_gemma":0.004664224,"domain_scores_codex":[0.9999093,0.00001086227,0.000007728934,0.00003864113,0.00001847541,0.0000149263],"domain_scores_gemma":[0.9998023,0.00003392668,0.0001021698,0.00001319768,0.00002371703,0.00002480127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001109706,0.00006705249,0.8481608,0.0001385404,0.0002241017,0.005532456,0.0007497072,0.0005143057,0.129152,0.0002760196,0.0003896928,0.01368571],"study_design_scores_gemma":[0.000006058074,0.00004223621,0.9967424,0.000005961081,0.00003178651,0.001481101,0.00009648401,0.0001780617,0.001153781,0.0001159087,0.0001436013,0.000002524208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989623,0.0002898407,0.000287845,0.00001801866,0.000001463639,0.000006550001,0.0001902868,0.000007132968,0.0002366755],"genre_scores_gemma":[0.9991768,0.0001688391,0.0002054287,0.00001198403,0.000003780463,0.000006031981,0.0002502466,0.000005128976,0.0001716418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00201224,"threshold_uncertainty_score":0.004582226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068992915522647,"score_gpt":0.2629277764009063,"score_spread":0.2422378472456798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}