{"id":"W4321764653","doi":"10.1101/2023.02.23.529808","title":"RNA in extracellular vesicles during adolescence reveal immune, energetic and microbial imprints of early life adversity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Emory University","keywords":"Extracellular vesicles; Immune system; RNA; Extracellular; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421763,0.0001489748,0.0002412275,0.0004027413,0.0002462638,0.0004459107,0.0001086823,0.0002984253,0.0009072233],"category_scores_gemma":[0.000362016,0.0001423629,0.0001997211,0.0001749609,0.0002215579,0.0002052275,0.0004416582,0.0004243942,0.0002003876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001473611,"about_ca_system_score_gemma":0.0001561306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009607816,"about_ca_topic_score_gemma":0.001799104,"domain_scores_codex":[0.9998738,0.00001750988,0.00000549367,0.00004124604,0.00002425676,0.00003762241],"domain_scores_gemma":[0.999837,0.00003423001,0.00006149058,0.00001056426,0.00002747918,0.00002913095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000628661,0.00004148987,0.1022766,0.0001179099,0.00008009242,0.000608506,0.0007447902,0.0000989098,0.884995,0.0002964071,0.0002606501,0.009851053],"study_design_scores_gemma":[0.000004230569,0.0001972246,0.9579017,0.0000412081,0.00004676616,0.0007225433,0.0008560299,0.0003968794,0.03778587,0.0002285472,0.001807324,0.00001183223],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970475,0.001356277,0.0005682632,0.00005667821,0.00001134305,0.000006569119,0.00047297,0.00001123155,0.0004691931],"genre_scores_gemma":[0.9967595,0.0008484105,0.0006844758,0.00009437658,0.00001403488,0.00003625984,0.0006542227,0.00001895174,0.0008898497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009607816,"threshold_uncertainty_score":0.003034949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008866395460301558,"score_gpt":0.2035645927589865,"score_spread":0.194698197298685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}