{"id":"W4321769669","doi":"10.1136/rmdopen-2022-002789","title":"Low rates of radiographic progression associated with clinical efficacy following up to 2 years of treatment with guselkumab: results from a phase 3, randomised, double-blind, placebo-controlled study of biologic-naïve patients with active psoriatic arthritis","year":2023,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Medicine; Double blind; Placebo; Internal medicine; Clinical trial; Randomized controlled trial; Physical therapy; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000561594,0.000354225,0.002343087,0.0002647222,0.0001031863,0.00002367198,0.000195557,0.0001095727,0.00001233591],"category_scores_gemma":[0.0003912526,0.0002026234,0.0002448668,0.00105907,0.0001219081,0.0001024798,0.0001087205,0.0001205175,0.000003521757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009169878,"about_ca_system_score_gemma":0.0001811433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162629,"about_ca_topic_score_gemma":0.001699363,"domain_scores_codex":[0.997095,0.0003381436,0.001059142,0.0006382355,0.000528202,0.0003412807],"domain_scores_gemma":[0.9967911,0.001297794,0.000937071,0.0004867625,0.0003139851,0.0001732853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.772903,0.01084546,0.1756561,0.000009421414,0.009471884,0.0001759623,0.003334063,0.00002585809,0.00002296161,2.812914e-7,0.00002138048,0.02753371],"study_design_scores_gemma":[0.7301496,0.0620391,0.2023515,0.00165768,0.001517551,6.529775e-7,0.001551158,0.00001235347,0.0005529953,0.000001408899,0.000005853647,0.0001601428],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825183,0.0001166655,0.000001572546,0.00002948562,0.0001041379,0.01677413,0.0003645195,0.00003770088,0.00005355139],"genre_scores_gemma":[0.9978919,0.00019747,0.000172468,0.000008442068,0.00002221267,0.0009914957,0.0006239054,0.00004288063,0.00004922733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05119365,"threshold_uncertainty_score":0.8262743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05758573899823239,"score_gpt":0.3872677352157663,"score_spread":0.3296819962175339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}