{"id":"W4321769669","doi":"10.1136/rmdopen-2022-002789","title":"Low rates of radiographic progression associated with clinical efficacy following up to 2 years of treatment with guselkumab: results from a phase 3, randomised, double-blind, placebo-controlled study of biologic-naïve patients with active psoriatic arthritis","year":2023,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Medicine; Double blind; Placebo; Internal medicine; Clinical trial; Randomized controlled trial; Physical therapy; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005805919,0.001106056,0.003100901,0.0004830101,0.0003780406,0.0009783934,0.0008036233,0.001639963,0.003405293],"category_scores_gemma":[0.004350029,0.0006782441,0.002370914,0.0004284067,0.001243175,0.001192098,0.0004442978,0.002587152,0.0004530883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129967,"about_ca_system_score_gemma":0.0008616282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258824,"about_ca_topic_score_gemma":0.0009091344,"domain_scores_codex":[0.9971378,0.001867139,0.0001909134,0.0003102446,0.000278701,0.0002152142],"domain_scores_gemma":[0.9953465,0.001619532,0.001714744,0.0003767482,0.0002063273,0.0007361277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9635009,0.008508089,0.004319857,0.0005686696,0.001257139,0.0000442889,0.0000909245,0.0002477373,0.00593329,0.00003028001,0.000227673,0.01527127],"study_design_scores_gemma":[0.5869486,0.364811,0.04412022,0.00003638952,0.00166206,0.0001173027,0.00004491831,0.0004454733,0.001238175,0.00008386084,0.0004536437,0.00003828996],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954401,0.002938515,0.0002648476,0.0001197213,0.00007390063,0.0004511522,0.0002848858,0.00003565894,0.0003910649],"genre_scores_gemma":[0.9974205,0.0007756932,0.0003544578,0.0001842768,0.0001377307,0.000362366,0.0003272631,0.00001092351,0.0004268162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005805919,"threshold_uncertainty_score":0.03070503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05758573899823239,"score_gpt":0.3872677352157663,"score_spread":0.3296819962175339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}