{"id":"W4321769995","doi":"10.1016/j.esmoop.2023.100787","title":"Immune-related adverse events as potential surrogates of immune checkpoint inhibitors’ efficacy: a systematic review and meta-analysis of randomized studies","year":2023,"lang":"en","type":"review","venue":"ESMO Open","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Hazard ratio; Randomized controlled trial; Confidence interval; Meta-analysis; Placebo; Odds ratio; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02914244,0.003219314,0.02310844,0.009862002,0.0006137625,0.003605398,0.002376995,0.002074509,0.003040115],"category_scores_gemma":[0.06643404,0.001605408,0.04077969,0.0107275,0.0009058214,0.002044284,0.001753065,0.001954792,0.0002788204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003113627,"about_ca_system_score_gemma":0.004389289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004376511,"about_ca_topic_score_gemma":0.008610479,"domain_scores_codex":[0.972226,0.01425799,0.008556987,0.002104538,0.002372135,0.0004823272],"domain_scores_gemma":[0.9313943,0.05460316,0.009294544,0.001476237,0.002826489,0.000405368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001260874,0.00001965774,0.003259233,0.4379962,0.5468871,0.00009324925,0.00005342403,0.0005099106,0.0001364735,0.0001520879,0.0004425836,0.009189137],"study_design_scores_gemma":[0.0005018825,0.0001572066,0.002752244,0.0326804,0.961809,0.00008427366,0.00003450167,0.0002008694,0.0001033934,0.000268944,0.001385569,0.00002166966],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002983909,0.9946518,0.0008502787,0.0001653653,0.0001108186,0.0003929165,0.0006501261,0.00002130375,0.000173446],"genre_scores_gemma":[0.1481544,0.841955,0.004283858,0.0009661639,0.0003021207,0.002672603,0.001350198,0.00004885839,0.0002667721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02914244,"threshold_uncertainty_score":0.1541218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09677872305832615,"score_gpt":0.4066153583180608,"score_spread":0.3098366352597347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}