{"id":"W4321781667","doi":"10.1038/s41467-023-36678-8","title":"Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; Common Fund; National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of Mental Health; NIH Office of the Director; National Institute on Drug Abuse; Cholangiocarcinoma Foundation; PSC Partners Seeking a Cure; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Primary sclerosing cholangitis; Genome-wide association study; Candidate gene; Biology; Locus (genetics); Genetics; Genetic association; In silico; Disease; Computational biology; Gene; Medicine; Single-nucleotide polymorphism; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616499,0.0001384484,0.0002446292,0.000202433,0.000414015,0.00008597633,0.0004793707,0.0001470785,0.00006678242],"category_scores_gemma":[0.0003846684,0.0001313838,0.0001086506,0.0008266611,0.0001206167,0.0001683009,0.0006827392,0.0007108847,0.00008911104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368752,"about_ca_system_score_gemma":0.0001716456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200969,"about_ca_topic_score_gemma":0.0006287218,"domain_scores_codex":[0.9989704,0.0001152108,0.0002345,0.0002410996,0.0002091262,0.0002296917],"domain_scores_gemma":[0.9973547,0.0002498132,0.00006101853,0.001848142,0.0001645027,0.0003217758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001632584,0.0004675218,0.8476537,0.0002504065,0.0005526441,0.00001165249,0.005821465,0.00002239982,0.06067879,0.0001885956,0.06150457,0.02268501],"study_design_scores_gemma":[0.0005581957,0.00003211023,0.9763745,0.00007188757,0.0001793528,0.000003081612,0.0004545831,0.00006453774,0.0001924315,0.00007280196,0.02186852,0.0001280189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981385,0.007444229,0.0000410385,0.008585991,0.00006354861,0.0004720735,0.0001318719,0.0001993738,0.001676881],"genre_scores_gemma":[0.990685,0.002204139,0.002648998,0.002378833,0.00006056357,0.00001571354,0.001207024,0.00002225092,0.0007774824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1287208,"threshold_uncertainty_score":0.5357678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05889149105728393,"score_gpt":0.379726007028619,"score_spread":0.3208345159713351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}