{"id":"W4321787519","doi":"10.1038/s41375-023-01837-9","title":"Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN)","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AOP Orphan; Swedish Orphan Biovitrum; RWTH Aachen University; Astellas Pharma; Deutsche Forschungsgemeinschaft; Syndax Pharmaceuticals; Sierra Oncology; Incyte; Agios Pharmaceuticals; Jazz Pharmaceuticals; Gilead Sciences; Celgene; AstraZeneca; Ariad Pharmaceuticals; Amgen; Pfizer; Alexion Pharmaceuticals","keywords":"Essential thrombocythemia; Pegylated interferon; Medicine; Myeloproliferative Disorders; Internal medicine; Hematology; Oncology; Polycythemia vera; Immunology; Ribavirin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003572636,0.00043559,0.001023519,0.0002107858,0.000137835,0.00002232307,0.0001848477,0.0001361954,0.00002634641],"category_scores_gemma":[0.0001721621,0.0002495194,0.0001269696,0.0007069361,0.0002218403,0.00007894641,0.0002466262,0.0003064967,0.0000112004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056973,"about_ca_system_score_gemma":0.0001660876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001636725,"about_ca_topic_score_gemma":0.0002141912,"domain_scores_codex":[0.9969531,0.0006571647,0.0008120757,0.0006509352,0.0005753007,0.0003513895],"domain_scores_gemma":[0.9981172,0.000330961,0.0004346592,0.0006602772,0.0003240128,0.0001328694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008430203,0.009716017,0.9649584,0.00007564208,0.001216127,0.0002414715,0.01202175,0.0000173992,0.003101192,0.00001368306,0.000063625,0.0001444866],"study_design_scores_gemma":[0.03399793,0.01446246,0.9227008,0.0002751244,0.0006090225,0.00003088142,0.003387729,0.0004999852,0.02380654,0.000006475625,0.000005567177,0.0002174505],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950277,0.00002666521,0.00000614368,0.00006800786,0.00007282163,0.004653184,0.00004187051,0.00007447404,0.0000291375],"genre_scores_gemma":[0.9991508,0.00001752526,0.00007231581,0.00007236285,0.00001255254,0.0004806279,0.00005064513,0.00005207021,0.0000911298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04225758,"threshold_uncertainty_score":0.9999957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905785071840068,"score_gpt":0.3048738658173676,"score_spread":0.285816015098967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}