{"id":"W4321787519","doi":"10.1038/s41375-023-01837-9","title":"Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN)","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AOP Orphan; Swedish Orphan Biovitrum; RWTH Aachen University; Astellas Pharma; Deutsche Forschungsgemeinschaft; Syndax Pharmaceuticals; Sierra Oncology; Incyte; Agios Pharmaceuticals; Jazz Pharmaceuticals; Gilead Sciences; Celgene; AstraZeneca; Ariad Pharmaceuticals; Amgen; Pfizer; Alexion Pharmaceuticals","keywords":"Essential thrombocythemia; Pegylated interferon; Medicine; Myeloproliferative Disorders; Internal medicine; Hematology; Oncology; Polycythemia vera; Immunology; Ribavirin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001114682,0.0005279568,0.0007105573,0.0008228446,0.0004867284,0.0008968727,0.0003851308,0.001058017,0.001005147],"category_scores_gemma":[0.001495556,0.0003714601,0.000643592,0.001070195,0.0003852766,0.0006076539,0.0004498872,0.0006447748,0.0002815059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813053,"about_ca_system_score_gemma":0.0002177511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009228825,"about_ca_topic_score_gemma":0.001003012,"domain_scores_codex":[0.9992471,0.0002540904,0.00007814859,0.0002056051,0.0001205474,0.00009453481],"domain_scores_gemma":[0.9990652,0.0001353249,0.000403085,0.0000708177,0.00008799758,0.0002376508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001925651,0.0002258801,0.9949763,0.00003131945,0.0003440702,0.0002186726,0.0001290191,0.00005512394,0.0005072276,0.0000258174,0.0001016593,0.001459369],"study_design_scores_gemma":[0.0001419051,0.0008956076,0.9977591,0.00001182604,0.0001452973,0.0004553552,0.0001300973,0.0001411735,0.00004347938,0.0000269811,0.0002417202,0.000007455084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988121,0.0006083354,0.00004700686,0.0000402097,0.000007234665,0.0000281386,0.0002103367,0.000002191076,0.0002444942],"genre_scores_gemma":[0.9992053,0.0001610706,0.00005247234,0.00005877346,0.00003056732,0.0000214688,0.0003564414,0.000001577808,0.0001123105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114682,"threshold_uncertainty_score":0.005895078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905785071840068,"score_gpt":0.3048738658173676,"score_spread":0.285816015098967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}