{"id":"W4321791532","doi":"10.1101/2023.02.24.529858","title":"FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Comunidad de Madrid","keywords":"Biology; Gliosis; Mutation; Zebrafish; Amyotrophic lateral sclerosis; Phenotype; Pathology; Gene; Genetics; Neuroscience; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008530867,0.0007518525,0.0003056032,0.0007104164,0.0001686384,0.0001947413,0.0003120715,0.000380818,0.001759764],"category_scores_gemma":[0.0001170839,0.0002212682,0.0002279348,0.0002167025,0.0004577298,0.0001184858,0.000366729,0.0004244246,0.0004213513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002947643,"about_ca_system_score_gemma":0.0002605163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008137263,"about_ca_topic_score_gemma":0.00121219,"domain_scores_codex":[0.9998293,0.00001510251,0.00002558192,0.00004985479,0.00005106696,0.00002910682],"domain_scores_gemma":[0.9998112,0.00003138805,0.00007043484,0.00001651748,0.00001263146,0.00005777485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092771,0.00002412004,0.000362073,0.00002505955,0.000008136941,0.00068949,0.00001201345,0.00007320719,0.9975986,0.00005720934,0.00003978331,0.001001111],"study_design_scores_gemma":[0.00003080918,0.000553928,0.0253193,0.00002456809,0.00004346572,0.004667111,0.0001004939,0.001174003,0.9655109,0.0002082431,0.002348823,0.00001819453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964287,0.0004189475,0.001256456,0.000043983,0.00001896215,0.00002057015,0.0008687627,0.0001183854,0.0008251682],"genre_scores_gemma":[0.9943439,0.0005448193,0.001361549,0.00005406225,0.000004747078,0.00003998792,0.001094146,0.00007570644,0.00248119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759764,"threshold_uncertainty_score":0.005887032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0336322549313412,"score_gpt":0.2727932159171165,"score_spread":0.2391609609857753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}