{"id":"W4321793210","doi":"10.1016/j.ijbiomac.2023.123803","title":"Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis","year":2023,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Phytochemistry and biological activity of medicinal plants","field":"Agricultural and Biological Sciences","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"National Natural Science Foundation of China","keywords":"Anoikis; Barrier function; Oxidative stress; Cell biology; Mitochondrion; Enterocyte; Chemistry; Intestinal mucosa; Apoptosis; Colitis; Programmed cell death; Biology; Immunology; Biochemistry; Internal medicine; Medicine; Small intestine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006731237,0.0003966527,0.0001568356,0.0002333149,0.0001423465,0.0002305775,0.00009300126,0.0002211312,0.001118331],"category_scores_gemma":[0.0000894629,0.00009038168,0.0002619739,0.0001058866,0.000127571,0.0002779955,0.0001639475,0.0006166356,0.0001365391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007155242,"about_ca_system_score_gemma":0.0001379349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003506404,"about_ca_topic_score_gemma":0.000630229,"domain_scores_codex":[0.9999503,0.00001052693,0.000003491896,0.00000904091,0.00001116328,0.00001548427],"domain_scores_gemma":[0.9999546,0.000006519725,0.00001239826,0.000003450015,0.000007993934,0.00001502471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002368217,0.00005042729,0.0001234844,0.0000849743,0.00001386798,0.00005503956,0.00001491891,0.00003638594,0.9971456,0.00005647832,0.00004277962,0.002139191],"study_design_scores_gemma":[0.00008503269,0.001180214,0.00768457,0.00004456272,0.0001682684,0.0002844407,0.0001383468,0.0009704108,0.9827094,0.0003333167,0.006382989,0.0000184601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991123,0.003657452,0.002698695,0.000245095,0.0001336816,0.00003860962,0.0001581304,0.00006081165,0.001884599],"genre_scores_gemma":[0.9959644,0.0009001992,0.001099873,0.0001576678,0.00002936746,0.00001816036,0.0001308693,0.00001112558,0.001688306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118331,"threshold_uncertainty_score":0.003741205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349256191645915,"score_gpt":0.2566568419138218,"score_spread":0.2331642799973627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}